PF-610355 (also known as PF-00610355 or PF-610,355) is an inhalable[1] ultra-long-acting β2 adrenoreceptor agonist[2] (ultra-LABA) that was investigated as a treatment of asthma and COPD by Pfizer.[3] It utilizes a sulfonamide agonist headgroup, that confers high levels of intrinsic crystallinity that could relate to the acidic sulfonamide motif supporting a zwitterionic form in the solid state. Optimization of pharmacokinetic properties minimized systemic exposure following inhalation and reduced systemically mediated adverse events.[4] Its in vivo duration on action confirmed its potential for once-daily use in humans. [5]
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| Routes of administration | Inhalation |
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| Formula | C34H39N3O6S |
| Molar mass | 617.76 g·mol−1 |
The investigation and development of PF-610355 were discontinued in 2011,[6] likely for strategic and regulatory reasons.[7]
References
edit- ^ Diderichsen PM, Cox E, Martin SW, Cleton A, Ribbing J (November 2013). "Predicted heart rate effect of inhaled PF-00610355, a long acting β-adrenoceptor agonist, in volunteers and patients with chronic obstructive pulmonary disease". British Journal of Clinical Pharmacology. 76 (5): 752–62. doi:10.1111/bcp.12080. PMC 3853534. PMID 23323609.
- ^ Cazzola M, Calzetta L, Matera MG (May 2011). "β(2) -adrenoceptor agonists: current and future direction". British Journal of Pharmacology. 163 (1): 4–17. doi:10.1111/j.1476-5381.2011.01216.x. PMC 3085864. PMID 21232045.
- ^ "Pfizer Pipeline as of January 27, 2010" (PDF). Pfizer Inc. p. 6. Archived from the original (PDF) on 6 September 2015. Retrieved 9 April 2016.
- ^ Glossop PA, Lane CA, Price DA, Bunnage ME, Lewthwaite RA, James K, et al. (September 2010). "Inhalation by design: novel ultra-long-acting β(2)-adrenoreceptor agonists for inhaled once-daily treatment of asthma and chronic obstructive pulmonary disease that utilize a sulfonamide agonist headgroup". Journal of Medicinal Chemistry. 53 (18): 6640–52. doi:10.1021/jm1005989. PMID 20804199.
- ^ Acton QA, ed. (2012-01-09). Issues in Medical Chemistry Edition. ScholarlyEditions. ISBN 978-1-464-96440-4.
- ^ "AdisInsight: PF 610355". Springer International Publishing AG. Retrieved 25 March 2016.
- ^ Cazzola M, Page CP, Rogliani P, Matera MG (April 2013). "β2-agonist therapy in lung disease". American Journal of Respiratory and Critical Care Medicine. 187 (7): 690–6. doi:10.1164/rccm.201209-1739PP. PMID 23348973.
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