PGDS

HPGDS
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1IYH, 1IYI, 1V40, 2CVD, 2VCQ, 2VCW, 2VCX, 2VCZ, 2VD0, 2VD1, 3EE2, 3KXO, 3VI5, 3VI7, 4EC0, 4EDY, 4EDZ, 4EE0, 5AIS, 5AIV, 5AIX
Identifiers
Aliases	HPGDS, GSTS, GSTS1-1, PGD2, PGDS, GSTS1, hematopoietic prostaglandin D synthase
External IDs	OMIM: 602598; MGI: 1859384; HomoloGene: 113741; GeneCards: HPGDS; OMA:HPGDS - orthologs
EC number	2.5.1.18
Gene location (Human)
Chr.	Chromosome 4 (human)
End	94,342,876 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	65,121,892 bp
RNA expression pattern
	Top expressed in
	testicle; ; placenta; ; Achilles tendon; ; gallbladder; ; synovial membrane; ; amniotic fluid; ; mucosa of transverse colon; ; rectum; ; synovial joint; ; tendon of biceps brachii;
	Top expressed in
	genital tubercle; ; primordial germ cell; ; calvaria; ; stroma of bone marrow; ; hair; ; Sertoli cell; ; yolk sac; ; ooblast; ; cornea; ; uterus;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	transferase activity; calcium ion binding; protein homodimerization activity; isomerase activity; metal ion binding; prostaglandin-D synthase activity; protein binding; magnesium ion binding; glutathione transferase activity;
Cellular component	cytoplasm; cytosol;
Biological process	prostaglandin metabolic process; locomotory behavior; lipid metabolism; cyclooxygenase pathway; fatty acid metabolic process; fatty acid biosynthetic process; prostaglandin biosynthetic process; glutathione derivative biosynthetic process; signal transduction; negative regulation of male germ cell proliferation; glutathione metabolic process;
	Sources:Amigo / QuickGO
Orthologs
	27306
	54486
	ENSG00000163106
	ENSMUSG00000029919
	O60760
	Q9JHF7
	NM_014485
	NM_019455
	NP_055300
	NP_062328
	Wikidata
View/Edit Human	View/Edit Mouse

PGDS protein is a protein that in humans is encoded by the HPGDS gene.^[5]^[6]^[7]^[8]

Prostaglandin-D synthase is a sigma class glutathione-S-transferase family member. The enzyme catalyzes the conversion of PGH2 to PGD2 and plays a role in the production of prostanoids in the immune system and mast cells. The presence of this enzyme can be used to identify the differentiation stage of human megakaryocytes.^[8]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000163106 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000029919 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Kanaoka Y, Ago H, Inagaki E, Nanayama T, Miyano M, Kikuno R, Fujii Y, Eguchi N, Toh H, Urade Y, Hayaishi O (Oct 1997). "Cloning and crystal structure of hematopoietic prostaglandin D synthase". Cell. 90 (6): 1085–95. doi:10.1016/S0092-8674(00)80374-8. PMID 9323136. S2CID 933875.
^ Mahmud I, Ueda N, Yamaguchi H, Yamashita R, Yamamoto S, Kanaoka Y, Urade Y, Hayaishi O (Dec 1997). "Prostaglandin D synthase in human megakaryoblastic cells". J Biol Chem. 272 (45): 28263–6. doi:10.1074/jbc.272.45.28263. PMID 9353279.
^ Jowsey IR, Thomson AM, Flanagan JU, Murdock PR, Moore GB, Meyer DJ, Murphy GJ, Smith SA, Hayes JD (Oct 2001). "Mammalian class Sigma glutathione S-transferases: catalytic properties and tissue-specific expression of human and rat GSH-dependent prostaglandin D2 synthases". Biochem J. 359 (Pt 3): 507–16. doi:10.1042/0264-6021:3590507. PMC 1222171. PMID 11672424.
^ ^a ^b "Entrez Gene: PGDS prostaglandin D2 synthase, hematopoietic".

Kanaoka Y, Urade Y (2004). "Hematopoietic prostaglandin D synthase". Prostaglandins Leukot. Essent. Fatty Acids. 69 (2–3): 163–7. doi:10.1016/S0952-3278(03)00077-2. PMID 12895599.
Suzuki T, Watanabe K, Kanaoka Y, et al. (1998). "Induction of hematopoietic prostaglandin D synthase in human megakaryocytic cells by phorbol ester". Biochem. Biophys. Res. Commun. 241 (2): 288–93. doi:10.1006/bbrc.1997.7803. PMID 9425264.
Tokugawa Y, Kunishige I, Kubota Y, et al. (1998). "Lipocalin-type prostaglandin D synthase in human male reproductive organs and seminal plasma". Biol. Reprod. 58 (2): 600–7. doi:10.1095/biolreprod58.2.600. PMID 9475419.
Pinzar E, Kanaoka Y, Inui T, et al. (2000). "Prostaglandin D synthase gene is involved in the regulation of non-rapid eye movement sleep". Proc. Natl. Acad. Sci. U.S.A. 97 (9): 4903–7. Bibcode:2000PNAS...97.4903P. doi:10.1073/pnas.090093997. PMC 18330. PMID 10781097.
Kanaoka Y, Fujimori K, Kikuno R, et al. (2000). "Structure and chromosomal localization of human and mouse genes for hematopoietic prostaglandin D synthase. Conservation of the ancestral genomic structure of sigma-class glutathione S-transferase". Eur. J. Biochem. 267 (11): 3315–22. doi:10.1046/j.1432-1327.2000.01362.x. PMID 10824118.
Fujimori K, Kanaoka Y, Sakaguchi Y, Urade Y (2001). "Transcriptional activation of the human hematopoietic prostaglandin D synthase gene in megakaryoblastic cells. Roles of the oct-1 element in the 5'-flanking region and the AP-2 element in the untranslated exon 1". J. Biol. Chem. 275 (51): 40511–6. doi:10.1074/jbc.M007688200. PMID 10998423.
Sui D, Wilson JE (2000). "Interaction of insulin-like growth factor binding protein-4, Miz-1, leptin, lipocalin-type prostaglandin D synthase, and granulin precursor with the N-terminal half of type III hexokinase". Arch. Biochem. Biophys. 382 (2): 262–74. doi:10.1006/abbi.2000.2019. PMID 11068878.
Noguchi E, Shibasaki M, Kamioka M, et al. (2002). "New polymorphisms of haematopoietic prostaglandin D synthase and human prostanoid DP receptor genes". Clin. Exp. Allergy. 32 (1): 93–6. doi:10.1046/j.0022-0477.2001.01261.x. PMID 12002745. S2CID 24779233.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Inoue T, Irikura D, Okazaki N, et al. (2003). "Mechanism of metal activation of human hematopoietic prostaglandin D synthase". Nat. Struct. Biol. 10 (4): 291–6. doi:10.1038/nsb907. PMID 12627223. S2CID 25214344.
Ando M, Murakami Y, Kojima F, et al. (2003). "Retrovirally introduced prostaglandin D2 synthase suppresses lung injury induced by bleomycin". Am. J. Respir. Cell Mol. Biol. 28 (5): 582–91. doi:10.1165/rcmb.2002-0162OC. PMID 12707014.
Inoue T, Okano Y, Kado Y, et al. (2005). "First determination of the inhibitor complex structure of human hematopoietic prostaglandin D synthase". J. Biochem. 135 (3): 279–83. doi:10.1093/jb/mvh033. PMID 15113825.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.

This article on a gene on human chromosome 4 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000163106 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000029919 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9323136-5] Kanaoka Y, Ago H, Inagaki E, Nanayama T, Miyano M, Kikuno R, Fujii Y, Eguchi N, Toh H, Urade Y, Hayaishi O (Oct 1997). "Cloning and crystal structure of hematopoietic prostaglandin D synthase". Cell. 90 (6): 1085–95. doi:10.1016/S0092-8674(00)80374-8. PMID 9323136. S2CID 933875.

[pmid9353279-6] Mahmud I, Ueda N, Yamaguchi H, Yamashita R, Yamamoto S, Kanaoka Y, Urade Y, Hayaishi O (Dec 1997). "Prostaglandin D synthase in human megakaryoblastic cells". J Biol Chem. 272 (45): 28263–6. doi:10.1074/jbc.272.45.28263. PMID 9353279.

[pmid11672424-7] Jowsey IR, Thomson AM, Flanagan JU, Murdock PR, Moore GB, Meyer DJ, Murphy GJ, Smith SA, Hayes JD (Oct 2001). "Mammalian class Sigma glutathione S-transferases: catalytic properties and tissue-specific expression of human and rat GSH-dependent prostaglandin D2 synthases". Biochem J. 359 (Pt 3): 507–16. doi:10.1042/0264-6021:3590507. PMC 1222171. PMID 11672424.

[entrez-8] "Entrez Gene: PGDS prostaglandin D2 synthase, hematopoietic".

[5]

[6]

[7]

[8]

[1]

[2]

[3]

[4]

PGDS

See also

References

Further reading