PGPEP1

The PGPEP1 gene in humans encodes the enzyme Pyroglutamyl-peptidase I.

PGPEP1
Identifiers
Aliases	PGPEP1, PAP-I, PGP, PGP-I, PGPI, Pcp, pyroglutamyl-peptidase I, PGI
External IDs	OMIM: 610694; MGI: 1913772; HomoloGene: 9793; GeneCards: PGPEP1; OMA:PGPEP1 - orthologs
Gene location (Human) Chr. Chromosome 19 (human) Band 19p13.11 Start 18,340,598 bp End 18,369,950 bp
Gene location (Mouse) Chr. Chromosome 8 (mouse) Band 8|8 B3.3 Start 70,646,435 bp End 70,660,388 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in cardia renal medulla tendon of biceps brachii pylorus inferior ganglion of vagus nerve internal globus pallidus external globus pallidus vena cava ventral tegmental area subthalamic nucleus Top expressed in right kidney proximal tubule ventricular zone human kidney epithelium of small intestine neural tube adrenal gland yolk sac jejunum ileum More reference expression data BioGPS More reference expression data
Gene ontology Molecular function peptidase activity cysteine-type peptidase activity hydrolase activity pyroglutamyl-peptidase activity Cellular component cytoplasm cytosol Biological process proteolysis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 54858 66522 Ensembl ENSG00000130517 ENSMUSG00000056204 UniProt Q9NXJ5 Q9ESW8 RefSeq (mRNA) NM_001300927 NM_001308366 NM_017712 NM_001329471 NM_001329476 NM_001329477 NM_001329478 NM_023217 RefSeq (protein) NP_001287856 NP_001295295 NP_001316400 NP_001316405 NP_001316406 NP_001316407 NP_060182 NP_075706 Location (UCSC) Chr 19: 18.34 – 18.37 Mb Chr 8: 70.65 – 70.66 Mb PubMed search
Wikidata
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Further reading

• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
• Valdivia A, Irazusta J, Fernández D, et al. (2005). "Pyroglutamyl peptidase I and prolyl endopeptidase in human semen: increased activity in necrozoospermia". Regul. Pept. 122 (2): 79–84. doi:10.1016/j.regpep.2004.05.005. PMID 15380924. S2CID 24844740.
• Minderman H, O'Loughlin KL, Pendyala L, Baer MR (2004). "VX-710 (biricodar) increases drug retention and enhances chemosensitivity in resistant cells overexpressing P-glycoprotein, multidrug resistance protein, and breast cancer resistance protein". Clin. Cancer Res. 10 (5): 1826–34. doi:10.1158/1078-0432.CCR-0914-3. PMID 15014037.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Dando PM, Fortunato M, Strand GB, et al. (2003). "Pyroglutamyl-peptidase I: cloning, sequencing, and characterisation of the recombinant human enzyme". Protein Expr. Purif. 28 (1): 111–9. doi:10.1016/S1046-5928(02)00632-0. PMID 12651114.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Gil J, Larrinaga G, Meana JJ, et al. (2002). "Regional and subcellular distribution of soluble aminopeptidase in the human and the rat brain: a comparative study". Neuropeptides. 35 (5–6): 276–84. doi:10.1054/npep.2001.0870. PMID 12030812. S2CID 39976173.
• Charli JL, Mendez M, Vargas MA, et al. (1990). "Pyroglutamyl peptidase II inhibition specifically increases recovery of TRH released from rat brain slices". Neuropeptides. 14 (3): 191–6. doi:10.1016/0143-4179(89)90044-9. PMID 2575716. S2CID 13735633.