PHF12

PHD finger protein 12 is a protein that in humans is encoded by the PHF12 gene.

PHF12
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2L9S, 2LKM
Identifiers
Aliases	PHF12, PF1, PHD finger protein 12
External IDs	MGI: 1924057; HomoloGene: 10841; GeneCards: PHF12; OMA:PHF12 - orthologs
Gene location (Human) Chr. Chromosome 17 (human) Band 17q11.2 Start 28,905,250 bp End 28,951,771 bp
Gene location (Mouse) Chr. Chromosome 11 (mouse) Band 11|11 B5 Start 77,873,580 bp End 77,921,365 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in sural nerve granulocyte bone marrow cells stromal cell of endometrium spleen right lung blood appendix gastric mucosa ganglionic eminence Top expressed in genital tubercle tail of embryo neural layer of retina granulocyte ventricular zone zygote superior frontal gyrus dentate gyrus of hippocampal formation granule cell thymus secondary oocyte More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transcription corepressor binding histone binding transcription corepressor activity RNA polymerase II transcription regulatory region sequence-specific DNA binding chromatin binding protein binding phosphatidylinositol binding metal ion binding Cellular component transcription repressor complex Sin3 complex nucleus nucleoplasm Sin3-type complex Biological process negative regulation of transcription, DNA-templated regulation of transcription, DNA-templated negative regulation of transcription by RNA polymerase II transcription, DNA-templated Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 57649 268448 Ensembl ENSG00000109118 ENSMUSG00000037791 UniProt Q96QT6 Q5SPL2 RefSeq (mRNA) NM_001033561 NM_001290131 NM_020889 NM_174852 RefSeq (protein) NP_001028733 NP_001277060 NP_065940 NP_777277 Location (UCSC) Chr 17: 28.91 – 28.95 Mb Chr 11: 77.87 – 77.92 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Interactions

PHF12 has been shown to interact with SIN3A.

Further reading

• Nousiainen M, Silljé HH, Sauer G, Nigg EA, Körner R (April 2006). "Phosphoproteome analysis of the human mitotic spindle". Proceedings of the National Academy of Sciences of the United States of America. 103 (14): 5391–6. Bibcode:2006PNAS..103.5391N. doi:10.1073/pnas.0507066103. PMC 1459365. PMID 16565220.
• Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP (August 2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proceedings of the National Academy of Sciences of the United States of America. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
• Yochum GS, Ayer DE (November 2002). "Role for the mortality factors MORF4, MRGX, and MRG15 in transcriptional repression via associations with Pf1, mSin3A, and Transducin-Like Enhancer of Split". Molecular and Cellular Biology. 22 (22): 7868–76. doi:10.1128/MCB.22.22.7868-7876.2002. PMC 134742. PMID 12391155.
• Nagase T, Kikuno R, Ishikawa K, Hirosawa M, Ohara O (April 2000). "Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro" (PDF). DNA Research. 7 (2): 143–50. doi:10.1093/dnares/7.2.143. PMID 10819331. S2CID 43194324.