PHF2

PHF2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3KQI, 3PTR, 3PU3, 3PU8, 3PUA, 3PUS
Identifiers
Aliases	PHF2, CENP-35, GRC5, JHDM1E, PHD finger protein 2, KDM7C
External IDs	OMIM: 604351; MGI: 1338034; HomoloGene: 3934; GeneCards: PHF2; OMA:PHF2 - orthologs
Gene location (Human)
Chr.	Chromosome 9 (human)
End	93,679,587 bp
Gene location (Mouse)
Chr.	Chromosome 13 (mouse)
End	49,024,595 bp
RNA expression pattern
	Top expressed in
	ganglionic eminence; ; ventricular zone; ; right hemisphere of cerebellum; ; cerebellar vermis; ; tendon of biceps brachii; ; internal globus pallidus; ; body of uterus; ; anterior pituitary; ; left ovary; ; canal of the cervix;
	Top expressed in
	ascending aorta; ; aortic valve; ; thymus; ; genital tubercle; ; ventricular zone; ; lacrimal gland; ; submandibular gland; ; lumbar subsegment of spinal cord; ; ganglionic eminence; ; ureter;
	More reference expression data
	n/a
Gene ontology
Molecular function	iron ion binding; histone H3-methyl-lysine-9 demethylase activity; transcription coactivator activity; dioxygenase activity; metal ion binding; methylated histone binding; protein binding; oxidoreductase activity; histone demethylase activity; zinc ion binding;
Cellular component	nucleoplasm; chromosome; nucleolus; chromosome, centromeric region; kinetochore; nucleus;
Biological process	regulation of transcription, DNA-templated; histone H3-K9 demethylation; protein demethylation; transcription, DNA-templated; negative regulation of ribosomal DNA heterochromatin assembly; liver development; chromatin organization;
	Sources:Amigo / QuickGO
Orthologs
	5253
	18676
	ENSG00000197724
	ENSMUSG00000038025
	O75151
	Q9WTU0
	NM_005392; NM_024517
	NM_011078
	NP_005383
	NP_035208
	Wikidata
View/Edit Human	View/Edit Mouse

PHD finger protein 2 is a protein that in humans is encoded by the PHF2 gene.^[5]

Function

This gene encodes a protein which contains a zinc finger-like PHD (plant homeodomain) finger, distinct from other classes of zinc finger motifs, and a hydrophobic and highly conserved domain. The PHD finger shows the typical Cys₄-His-Cys₃ arrangement. PHD finger genes are thought to belong to a diverse group of transcriptional regulators possibly affecting eukaryotic gene expression by influencing chromatin structure.

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000197724 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000038025 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: PHD finger protein 2". Retrieved 2016-04-09.

PHF2

Function

References

Further reading