PHLPP (gene)

PH domain and leucine rich repeat protein phosphatase, also known as PHLPP, is an enzyme which in humans is encoded by the PHLPP gene.

PHLPP1
Identifiers
Aliases	PHLPP1, PHLPP, PLEKHE1, SCOP, PPM3A, PH domain and leucine rich repeat protein phosphatase 1
External IDs	OMIM: 609396; MGI: 2138327; HomoloGene: 11015; GeneCards: PHLPP1; OMA:PHLPP1 - orthologs
Gene location (Human) Chr. Chromosome 18 (human) Band 18q21.33 Start 62,715,541 bp End 62,980,433 bp
Gene location (Mouse) Chr. Chromosome 1 (mouse) Band 1|1 E2.1 Start 106,099,482 bp End 106,321,980 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in corpus callosum ventricular zone internal globus pallidus middle frontal gyrus inferior ganglion of vagus nerve optic nerve ganglionic eminence buccal mucosa cell Region I of hippocampus proper external globus pallidus Top expressed in deep cerebellar nuclei lateral geniculate nucleus globus pallidus substantia nigra medial geniculate nucleus pontine nuclei dorsal tegmental nucleus medial dorsal nucleus mammillary body superior colliculus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function phosphoprotein phosphatase activity metal ion binding protein binding catalytic activity hydrolase activity protein serine/threonine phosphatase activity Cellular component cytosol membrane nucleus cytoplasm plasma membrane nuclear membrane photoreceptor inner segment photoreceptor outer segment membrane Biological process regulation of apoptotic process regulation of MAPK cascade protein dephosphorylation entrainment of circadian clock regulation of JNK cascade regulation of T cell anergy regulation of p38MAPK cascade apoptotic process regulation of protein kinase C signaling negative regulation of protein kinase B signaling Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 23239 98432 Ensembl ENSG00000081913 ENSMUSG00000044340 UniProt O60346 Q8CHE4 RefSeq (mRNA) NM_194449 NM_133821 RefSeq (protein) NP_919431 NP_598582 Location (UCSC) Chr 18: 62.72 – 62.98 Mb Chr 1: 106.1 – 106.32 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

See also

• PHLPP

Further reading

• Nakajima D, Okazaki N, Yamakawa H, et al. (2003). "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones". DNA Res. 9 (3): 99–106. doi:10.1093/dnares/9.3.99. PMID 12168954.
• Nagase T, Ishikawa K, Miyajima N, et al. (1998). "Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Res. 5 (1): 31–9. doi:10.1093/dnares/5.1.31. PMID 9628581.
• Shimizu K, Okada M, Takano A, Nagai K (2000). "SCOP, a novel gene product expressed in a circadian manner in rat suprachiasmatic nucleus". FEBS Lett. 458 (3): 363–9. doi:10.1016/S0014-5793(99)01190-4. PMID 10570941. S2CID 38044717.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Gao T, Furnari F, Newton AC (2005). "PHLPP: a phosphatase that directly dephosphorylates Akt, promotes apoptosis, and suppresses tumor growth". Mol. Cell. 18 (1): 13–24. doi:10.1016/j.molcel.2005.03.008. PMID 15808505.
• Zhang Y, Wolf-Yadlin A, Ross PL, et al. (2005). "Time-resolved mass spectrometry of tyrosine phosphorylation sites in the epidermal growth factor receptor signaling network reveals dynamic modules". Mol. Cell. Proteomics. 4 (9): 1240–50. doi:10.1074/mcp.M500089-MCP200. PMID 15951569.
• Nusbaum C, Zody MC, Borowsky ML, et al. (2005). "DNA sequence and analysis of human chromosome 18". Nature. 437 (7058): 551–5. Bibcode:2005Natur.437..551N. doi:10.1038/nature03983. PMID 16177791.
• Brognard J, Sierecki E, Gao T, Newton AC (2007). "PHLPP and a second isoform, PHLPP2, differentially attenuate the amplitude of Akt signaling by regulating distinct Akt isoforms". Mol. Cell. 25 (6): 917–31. doi:10.1016/j.molcel.2007.02.017. PMID 17386267.