PIF1 5'-to-3' DNA helicase

PIF1 5'-to-3' DNA helicase is a protein that in humans is encoded by the PIF1 gene. [5]

PIF1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesPIF1, C15orf20, PIF, PIF1 5'-to-3' DNA helicase
External IDsOMIM: 610953; MGI: 2143057; HomoloGene: 99775; GeneCards: PIF1; OMA:PIF1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001286496
NM_001286497
NM_001286499
NM_025049

NM_172453
NM_001357526
NM_001357527

RefSeq (protein)

NP_001273425
NP_001273426
NP_001273428
NP_079325

NP_766041
NP_001344455
NP_001344456

Location (UCSC)Chr 15: 64.82 – 64.83 MbChr 9: 65.59 – 65.6 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

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This gene encodes a DNA-dependent adenosine triphosphate (ATP)-metabolizing enzyme that functions as a 5' to 3' DNA helicase. The encoded protein can resolve G-quadruplex structures and RNA-DNA hybrids at the ends of chromosomes. It also prevents telomere elongation by inhibiting the actions of telomerase. Alternative splicing and the use of alternative start codons results in multiple isoforms that are differentially localized to either the mitochondria or the nucleus. [provided by RefSeq, Nov 2013].

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000140451Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000041064Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: PIF1 5'-to-3' DNA helicase". Retrieved 2018-05-17.

Further reading

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  • Overview of all the structural information available in the PDB for UniProt: Q9H611 (ATP-dependent DNA helicase PIF1) at the PDBe-KB.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.