PIWIL1

Piwi-like protein 1 is a protein that in humans is encoded by the PIWIL1 gene.

PIWIL1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2L5C, 2L5D, 3O3I, 3O6E, 3O7V
Identifiers
Aliases	PIWIL1, CT80.1, HIWI, MIWI, PIWI, piwi like RNA-mediated gene silencing 1
External IDs	OMIM: 605571; MGI: 1928897; HomoloGene: 37963; GeneCards: PIWIL1; OMA:PIWIL1 - orthologs
Gene location (Human) Chr. Chromosome 12 (human) Band 12q24.33 Start 130,337,887 bp End 130,372,637 bp
Gene location (Mouse) Chr. Chromosome 5 (mouse) Band 5 G1.3|5 67.86 cM Start 128,779,588 bp End 128,832,538 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right testis left testis gonad testicle anterior pituitary right lobe of thyroid gland right uterine tube canal of the cervix spleen superior frontal gyrus Top expressed in spermatocyte seminiferous tubule zygote secondary oocyte spermatid female urethra primary oocyte primary spermatocyte embryo Gonadal ridge More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein kinase binding RNA binding single-stranded RNA binding nucleic acid binding protein binding mRNA binding nuclease activity endonuclease activity endoribonuclease activity hydrolase activity metal ion binding piRNA binding protein-containing complex binding polysome binding mRNA cap binding complex binding Cellular component polysome nucleus mRNA cap binding complex dense body P granule cytoplasm chromatoid body Biological process multicellular organism development regulation of translation meiosis cell differentiation gene silencing spermatogenesis negative regulation of transposition piRNA metabolic process nucleic acid phosphodiester bond hydrolysis RNA phosphodiester bond hydrolysis, endonucleolytic spermatid development Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9271 57749 Ensembl ENSG00000275051 ENSG00000125207 ENSMUSG00000029423 UniProt Q96J94 Q9JMB7 RefSeq (mRNA) NM_001190971 NM_004764 NM_021311 RefSeq (protein) NP_001177900 NP_004755 NP_067286 Location (UCSC) Chr 12: 130.34 – 130.37 Mb Chr 5: 128.78 – 128.83 Mb PubMed search
Wikidata
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This gene encodes a member of the PIWI subfamily of Argonaute proteins, evolutionarily conserved proteins containing both PAZ and Piwi motifs that play important roles in stem cell self-renewal, RNA silencing, and translational regulation in diverse organisms.

The encoded protein may play a role as an intrinsic regulator of the self-renewal capacity of germline and hematopoietic stem cells.

Further reading

• Sharma AK, Nelson MC, Brandt JE, et al. (2001). "Human CD34(+) stem cells express the hiwi gene, a human homologue of the Drosophila gene piwi". Blood. 97 (2): 426–34. doi:10.1182/blood.V97.2.426. PMID 11154219.
• Qiao D, Zeeman AM, Deng W, et al. (2002). "Molecular characterization of hiwi, a human member of the piwi gene family whose overexpression is correlated to seminomas". Oncogene. 21 (25): 3988–99. doi:10.1038/sj.onc.1205505. PMID 12037681. S2CID 6078065.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Tahbaz N, Kolb FA, Zhang H, et al. (2004). "Characterization of the interactions between mammalian PAZ PIWI domain proteins and Dicer". EMBO Rep. 5 (2): 189–94. doi:10.1038/sj.embor.7400070. PMC 1298981. PMID 14749716.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Liu X, Sun Y, Guo J, et al. (2006). "Expression of hiwi gene in human gastric cancer was associated with proliferation of cancer cells". Int. J. Cancer. 118 (8): 1922–9. doi:10.1002/ijc.21575. PMID 16287078. S2CID 8616640.
• Taubert H, Greither T, Kaushal D, et al. (2007). "Expression of the stem cell self-renewal gene Hiwi and risk of tumour-related death in patients with soft-tissue sarcoma". Oncogene. 26 (7): 1098–100. doi:10.1038/sj.onc.1209880. PMID 16953229.
• Sugimoto K, Kage H, Aki N, et al. (2007). "The induction of H3K9 methylation by PIWIL4 at the p16Ink4a locus". Biochem. Biophys. Res. Commun. 359 (3): 497–502. doi:10.1016/j.bbrc.2007.05.136. PMID 17544373.