PKRS or PKRs can refer to:
- Pakistani rupees, the currency of Pakistan
- Password Authenticated Key Retrieval Scheme, a type of password-based public-key cryptography. See IEEE P1363.
- Pusat Keamanan Rakyat Sementara (literally Temporary Center for People's Safety), an organisation led by Andi Abdullah Bau Massepe in support of Indonesian independence
- Pertahanan Keamanan Rakyat Semesta (translated as "Universal People's Defense and Security" or "Nation in Arms"), a system similar to conscription in Indonesia
- Pokérus, an aspect of Pokémon gameplay introduced in Pokémon Gold and Silver