PKS may refer to:
- Pammal K. Sambandam, a 2002 Tamil language comedy film
- Państwowa Komunikacja Samochodowa, Polish transport organization
- Parkstone railway station, station code
- Phi Kappa Sigma International Fraternity
- Parkes Catalogue of Radio Sources, an astronomical catalogue
- Polyketide synthases, enzymes
- Prosperous Justice Party (Partai Keadilan Sejahtera), Indonesia
- Serbian Chamber of Commerce