PLA2G4B

Phospholipase A₂, group IVB (cytosolic) is an enzyme that in humans is encoded by the PLA2G4B gene.

JMJD7-PLA2G4B
Available structures PDB Human UniProt search: PDBe RCSB List of PDB id codes 1BCI, 1CJY, 1RLW
Identifiers
Aliases	JMJD7-PLA2G4B, HsT16992, cPLA2-beta, PLA2G4B, JMJD7-PLA2G4B readthrough
External IDs	HomoloGene: 130533; GeneCards: JMJD7-PLA2G4B; OMA:JMJD7-PLA2G4B - orthologs
Gene location (Human) Chr. Chromosome 15 (human) Band 15q15.1 Start 41,828,095 bp End 41,848,155 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right hemisphere of cerebellum skin of abdomen skin of leg granulocyte vagina left ovary right lobe of thyroid gland left lobe of thyroid gland right ovary ectocervix n/a More reference expression data BioGPS More reference expression data
Gene ontology Molecular function calcium ion binding phospholipase activity calcium-dependent phospholipase A2 activity metal ion binding calcium-dependent phospholipid binding hydrolase activity phospholipase A2 activity phospholipase A1 activity lysophospholipase activity Cellular component cytoplasm cytosol endosome early endosome membrane membrane mitochondrial membranes extracellular region mitochondrion mitochondrial inner membrane Biological process phosphatidic acid biosynthetic process phosphatidylserine acyl-chain remodeling phosphatidylethanolamine acyl-chain remodeling glycerophospholipid catabolic process lipid metabolism lipid catabolic process IRE1-mediated unfolded protein response birth phosphatidylglycerol acyl-chain remodeling phospholipid catabolic process phospholipid metabolic process metabolism inflammatory response arachidonic acid metabolic process phosphatidylcholine acyl-chain remodeling calcium-mediated signaling Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 8681 n/a Ensembl ENSG00000168970 n/a UniProt P0C869 n/a RefSeq (mRNA) NM_001198588 NM_005090 n/a RefSeq (protein) NP_001185517 NP_005081 n/a Location (UCSC) Chr 15: 41.83 – 41.85 Mb n/a PubMed search n/a
Wikidata
View/Edit Human

See also

• Phospholipase A₂

Further reading

• Schröder HC, Perovic S, Kavsan V, et al. (1998). "Mechanisms of prionSc- and HIV-1 gp120 induced neuronal cell death". Neurotoxicology. 19 (4–5): 683–8. PMID 9745929.
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Mavoungou E, Georges-Courbot MC, Poaty-Mavoungou V, et al. (1997). "HIV and SIV envelope glycoproteins induce phospholipase A2 activation in human and macaque lymphocytes". J. Acquir. Immune Defic. Syndr. Hum. Retrovirol. 16 (1): 1–9. doi:10.1097/00042560-199709010-00001. PMID 9377118.
• Underwood KW, Song C, Kriz RW, et al. (1998). "A novel calcium-independent phospholipase A2, cPLA2-gamma, that is prenylated and contains homology to cPLA2". J. Biol. Chem. 273 (34): 21926–32. doi:10.1074/jbc.273.34.21926. PMID 9705332.
• Pickard RT, Strifler BA, Kramer RM, Sharp JD (1999). "Molecular cloning of two new human paralogs of 85-kDa cytosolic phospholipase A2". J. Biol. Chem. 274 (13): 8823–31. doi:10.1074/jbc.274.13.8823. PMID 10085124.
• Song C, Chang XJ, Bean KM, et al. (1999). "Molecular characterization of cytosolic phospholipase A2-beta". J. Biol. Chem. 274 (24): 17063–7. doi:10.1074/jbc.274.24.17063. PMID 10358058.
• Degousee N, Ghomashchi F, Stefanski E, et al. (2002). "Groups IV, V, and X phospholipases A2s in human neutrophils: role in eicosanoid production and gram-negative bacterial phospholipid hydrolysis". J. Biol. Chem. 277 (7): 5061–73. doi:10.1074/jbc.M109083200. PMID 11741884.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Pope SN, Lee IR (2005). "Yeast two-hybrid identification of prostatic proteins interacting with human sex hormone-binding globulin". J. Steroid Biochem. Mol. Biol. 94 (1–3): 203–8. doi:10.1016/j.jsbmb.2005.01.007. PMID 15862967. S2CID 9746088.
• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
• Ghosh M, Loper R, Gelb MH, Leslie CC (2006). "Identification of the expressed form of human cytosolic phospholipase A2beta (cPLA2beta): cPLA2beta3 is a novel variant localized to mitochondria and early endosomes". J. Biol. Chem. 281 (24): 16615–24. doi:10.1074/jbc.M601770200. PMID 16617059.