PLA2G4E (gene)

Phospholipase A2 group IVE is a protein that in humans is encoded by the PLA2G4E gene.

PLA2G4E
Identifiers
Aliases	PLA2G4E, phospholipase A2 group IVE
External IDs	MGI: 1919144; HomoloGene: 65339; GeneCards: PLA2G4E; OMA:PLA2G4E - orthologs
Gene location (Human) Chr. Chromosome 15 (human) Band 15q15.1 Start 41,981,394 bp End 42,051,190 bp
Gene location (Mouse) Chr. Chromosome 2 (mouse) Band 2|2 E5 Start 119,996,893 bp End 120,075,816 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in skin of leg skin of abdomen gonad tonsil vagina skeletal muscle tissue muscle of leg gastrocnemius muscle muscle of thigh olfactory zone of nasal mucosa Top expressed in lip muscle of thigh knee joint esophagus quadriceps femoris muscle soleus muscle skeletal muscle tissue gastrocnemius muscle temporal muscle primary visual cortex More reference expression data BioGPS n/a
Gene ontology Molecular function hydrolase activity phospholipase activity metal ion binding phospholipase A2 activity phospholipase A1 activity lysophospholipase activity calcium ion binding calcium-dependent phospholipid binding calcium-dependent phospholipase A2 activity Cellular component lysosomal membrane cytosol cytoplasm lysosome membrane Biological process lipid metabolism lipid catabolic process metabolism phosphatidylserine acyl-chain remodeling phosphatidylethanolamine acyl-chain remodeling phospholipid metabolic process phosphatidylcholine acyl-chain remodeling phospholipid catabolic process phosphatidylinositol acyl-chain remodeling glycerophospholipid catabolic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 123745 329502 Ensembl ENSG00000188089 ENSMUSG00000050211 UniProt Q3MJ16 Q50L42 RefSeq (mRNA) NM_001080490 NM_001206670 NM_001395548 NM_198442 NM_177845 NM_001363090 NM_001363091 NM_001395470 RefSeq (protein) NP_001193599 NP_808513 NP_001350019 NP_001350020 NP_001382399 Location (UCSC) Chr 15: 41.98 – 42.05 Mb Chr 2: 120 – 120.08 Mb PubMed search
Wikidata
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Function

This gene encodes a member of the cytosolic phospholipase A2 group IV family. Members of this family are involved in regulation of membrane tubule-mediated transport. The enzyme encoded by this member of the family plays a role in trafficking through the clathrin-independent endocytic pathway. The enzyme regulates the recycling process via formation of tubules that transport internalized clathrin-independent cargo proteins back to the cell surface. [provided by RefSeq, Jan 2017].

Further reading

• Talmud PJ, Drenos F, Shah S, Shah T, Palmen J, Verzilli C, Gaunt TR, Pallas J, Lovering R, Li K, Casas JP, Sofat R, Kumari M, Rodriguez S, Johnson T, Newhouse SJ, Dominiczak A, Samani NJ, Caulfield M, Sever P, Stanton A, Shields DC, Padmanabhan S, Melander O, Hastie C, Delles C, Ebrahim S, Marmot MG, Smith GD, Lawlor DA, Munroe PB, Day IN, Kivimaki M, Whittaker J, Humphries SE, Hingorani AD (November 2009). "Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip". Am. J. Hum. Genet. 85 (5): 628–42. doi:10.1016/j.ajhg.2009.10.014. PMC 2775832. PMID 19913121.
• Bailey SD, Xie C, Do R, Montpetit A, Diaz R, Mohan V, Keavney B, Yusuf S, Gerstein HC, Engert JC, Anand S (October 2010). "Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study". Diabetes Care. 33 (10): 2250–3. doi:10.2337/dc10-0452. PMC 2945168. PMID 20628086.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.