PLXNA2

Plexin-A2 is a protein that in humans is coded by the PLXNA2 gene.

PLXNA2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3Q3J
Identifiers
Aliases	PLXNA2, OCT, PLXN2, plexin A2
External IDs	OMIM: 601054; MGI: 107684; HomoloGene: 56427; GeneCards: PLXNA2; OMA:PLXNA2 - orthologs
Gene location (Human) Chr. Chromosome 1 (human) Band 1q32.2 Start 208,022,242 bp End 208,244,384 bp
Gene location (Mouse) Chr. Chromosome 1 (mouse) Band 1|1 H6 Start 194,300,526 bp End 194,499,177 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ganglionic eminence body of pancreas right lung upper lobe of left lung left ovary right hemisphere of cerebellum right ovary postcentral gyrus left coronary artery right coronary artery Top expressed in ganglionic eminence Rostral migratory stream medial ganglionic eminence olfactory tubercle hair follicle lateral septal nucleus nucleus accumbens internal carotid artery ventromedial nucleus external carotid artery More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding semaphorin receptor activity identical protein binding Cellular component integral component of membrane plasma membrane semaphorin receptor complex membrane integral component of plasma membrane Biological process somitogenesis cell surface receptor signaling pathway regulation of axon extension involved in axon guidance cerebellar granule cell precursor tangential migration branchiomotor neuron axon guidance limb bud formation neural tube development semaphorin-plexin signaling pathway signal transduction pharyngeal system development centrosome localization regulation of cell migration negative regulation of cell adhesion regulation of cell shape regulation of GTPase activity positive regulation of axonogenesis semaphorin-plexin signaling pathway involved in axon guidance Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5362 18845 Ensembl ENSG00000076356 ENSMUSG00000026640 UniProt O75051 P70207 RefSeq (mRNA) NM_025179 NM_008882 RefSeq (protein) NP_079455 NP_032908 Location (UCSC) Chr 1: 208.02 – 208.24 Mb Chr 1: 194.3 – 194.5 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

This gene encodes a member of the plexin-A family of semaphorin co-receptors. Semaphorins are a large family of secreted or membrane-bound proteins that mediate repulsive effects on axon pathfinding during nervous system development. A subset of semaphorins are recognized by plexin-A/neuropilin transmembrane receptor complexes, triggering a cellular signal transduction cascade that leads to axon repulsion. This plexin-A family member is thought to transduce signals from semaphorin-3A and -3C.

In some studies, the PLXNA2 gene is associated with schizophrenia. and anxiety. PLXNA2 is a candidate gene for intellectual disability and possibly facial dysmorphism and congenital heart disease

Further reading

• Negishi M, Oinuma I, Katoh H (2005). "Plexins: axon guidance and signal transduction". Cell. Mol. Life Sci. 62 (12): 1363–71. doi:10.1007/s00018-005-5018-2. PMC 11139078. PMID 15818466. S2CID 32299864.
• Seki N, Ohira M, Nagase T, et al. (1998). "Characterization of cDNA clones in size-fractionated cDNA libraries from human brain". DNA Res. 4 (5): 345–9. doi:10.1093/dnares/4.5.345. PMID 9455484.
• Tamagnone L, Artigiani S, Chen H, et al. (1999). "Plexins are a large family of receptors for transmembrane, secreted, and GPI-anchored semaphorins in vertebrates". Cell. 99 (1): 71–80. doi:10.1016/S0092-8674(00)80063-X. PMID 10520995. S2CID 17386412.
• Nakayama M, Kikuno R, Ohara O (2003). "Protein–Protein Interactions Between Large Proteins: Two-Hybrid Screening Using a Functionally Classified Library Composed of Long cDNAs". Genome Res. 12 (11): 1773–84. doi:10.1101/gr.406902. PMC 187542. PMID 12421765.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Clark HF, Gurney AL, Abaya E, et al. (2003). "The Secreted Protein Discovery Initiative (SPDI), a Large-Scale Effort to Identify Novel Human Secreted and Transmembrane Proteins: A Bioinformatics Assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
• Mah S, Nelson MR, Delisi LE, et al. (2006). "Identification of the semaphorin receptor PLXNA2 as a candidate for susceptibility to schizophrenia". Mol. Psychiatry. 11 (5): 471–8. doi:10.1038/sj.mp.4001785. PMID 16402134.
• Fujii T, Iijima Y, Kondo H, et al. (2007). "Failure to confirm an association between the PLXNA2 gene and schizophrenia in a Japanese population". Prog. Neuropsychopharmacol. Biol. Psychiatry. 31 (4): 873–7. doi:10.1016/j.pnpbp.2007.01.027. PMID 17346868. S2CID 46003583.