POLD4

DNA polymerase delta subunit 4, also known as DNA polymerase delta subunit p12, is a protein that in humans is encoded by the POLD4 gene. It is a component of the DNA polymerase delta complex.

POLD4
Identifiers
Aliases	POLD4, POLDS, p12, polymerase (DNA) delta 4, accessory subunit, DNA polymerase delta 4, accessory subunit
External IDs	OMIM: 611525; MGI: 1916995; HomoloGene: 10909; GeneCards: POLD4; OMA:POLD4 - orthologs
Gene location (Human) Chr. Chromosome 11 (human) Band 11q13.2 Start 67,350,772 bp End 67,356,972 bp
Gene location (Mouse) Chr. Chromosome 19 (mouse) Band 19|19 A Start 4,281,953 bp End 4,283,688 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in mucosa of transverse colon right lobe of liver granulocyte duodenum appendix lymph node Descending thoracic aorta blood left coronary artery right coronary artery Top expressed in spleen white adipose tissue urinary bladder granulocyte adrenal gland bone marrow pancreas islet of Langerhans lip muscle of thigh More reference expression data BioGPS n/a
Gene ontology Molecular function protein binding DNA-directed DNA polymerase activity Cellular component delta DNA polymerase complex nucleoplasm nucleolus mitochondrion cytosol nucleus Biological process DNA-dependent DNA replication nucleotide-excision repair, DNA gap filling DNA synthesis involved in DNA repair translesion synthesis transcription-coupled nucleotide-excision repair nucleotide-excision repair, DNA incision telomere maintenance nucleotide-excision repair, DNA incision, 5'-to lesion DNA repair cellular response to DNA damage stimulus telomere maintenance via semi-conservative replication DNA replication DNA mismatch repair Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 57804 69745 Ensembl ENSG00000175482 ENSMUSG00000024854 UniProt Q9HCU8 Q9CWP8 RefSeq (mRNA) NM_001256870 NM_021173 NM_027196 RefSeq (protein) NP_001243799 NP_066996 NP_081472 Location (UCSC) Chr 11: 67.35 – 67.36 Mb Chr 19: 4.28 – 4.28 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Further reading

• Xie B, Mazloum N, Liu L, et al. (2002). "Reconstitution and characterization of the human DNA polymerase delta four-subunit holoenzyme". Biochemistry. 41 (44): 13133–42. doi:10.1021/bi0262707. PMID 12403614.
• Selak N, Bachrati CZ, Shevelev I, et al. (2008). "The Bloom's syndrome helicase (BLM) interacts physically and functionally with p12, the smallest subunit of human DNA polymerase delta". Nucleic Acids Res. 36 (16): 5166–79. doi:10.1093/nar/gkn498. PMC 2532730. PMID 18682526.
• Bae SH, Bae KH, Kim JA, Seo YS (2001). "RPA governs endonuclease switching during processing of Okazaki fragments in eukaryotes". Nature. 412 (6845): 456–61. doi:10.1038/35086609. PMID 11473323. S2CID 4337704.
• Matsumoto Y, Kim K, Hurwitz J, et al. (1999). "Reconstitution of proliferating cell nuclear antigen-dependent repair of apurinic/apyrimidinic sites with purified human proteins". J. Biol. Chem. 274 (47): 33703–8. doi:10.1074/jbc.274.47.33703. PMID 10559261.
• Liu G, Warbrick E (2006). "The p66 and p12 subunits of DNA polymerase delta are modified by ubiquitin and ubiquitin-like proteins". Biochem. Biophys. Res. Commun. 349 (1): 360–6. doi:10.1016/j.bbrc.2006.08.049. PMID 16934752.
• Tsurimoto T, Shinozaki A, Yano M, et al. (2005). "Human Werner helicase interacting protein 1 (WRNIP1) functions as a novel modulator for DNA polymerase delta". Genes Cells. 10 (1): 13–22. doi:10.1111/j.1365-2443.2004.00812.x. PMID 15670210. S2CID 24977510.
• Wood RD, Shivji MK (1997). "Which DNA polymerases are used for DNA-repair in eukaryotes?". Carcinogenesis. 18 (4): 605–10. doi:10.1093/carcin/18.4.605. PMID 9111189.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Huang QM, Akashi T, Masuda Y, et al. (2010). "Roles of POLD4, smallest subunit of DNA polymerase delta, in nuclear structures and genomic stability of human cells". Biochem. Biophys. Res. Commun. 391 (1): 542–6. doi:10.1016/j.bbrc.2009.11.094. PMID 19931513.
• Li H, Xie B, Zhou Y, et al. (2006). "Functional roles of p12, the fourth subunit of human DNA polymerase delta". J. Biol. Chem. 281 (21): 14748–55. doi:10.1074/jbc.M600322200. PMID 16510448.
• Liu L, Mo J, Rodriguez-Belmonte EM, Lee MY (2000). "Identification of a fourth subunit of mammalian DNA polymerase delta". J. Biol. Chem. 275 (25): 18739–44. doi:10.1074/jbc.M001217200. PMID 10751307.