DNA-directed RNA polymerase III subunit RPC4 is an enzyme that in humans is encoded by the POLR3D gene.[5][6][7]

POLR3D
Identifiers
AliasesPOLR3D, BN51T, RPC4, RPC53, TSBN51, polymerase (RNA) III subunit D, RNA polymerase III subunit D, C53
External IDsOMIM: 187280; MGI: 1914315; HomoloGene: 1303; GeneCards: POLR3D; OMA:POLR3D - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001722

NM_001164082
NM_025945

RefSeq (protein)

NP_001713

NP_001157554
NP_080221

Location (UCSC)Chr 8: 22.25 – 22.25 MbChr 14: 70.68 – 70.68 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

This gene complements a temperature-sensitive mutant isolated from the BHK-21 Syrian hamster cell line. It leads to a block in progression through the G1 phase of the cell cycle at nonpermissive temperatures.[7]

Interactions

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POLR3D has been shown to interact with POLR3E.[5]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000168495Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000000776Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b Hu P, Wu S, Sun Y, Yuan CC, Kobayashi R, Myers MP, Hernandez N (Oct 2002). "Characterization of human RNA polymerase III identifies orthologues for Saccharomyces cerevisiae RNA polymerase III subunits" (PDF). Mol Cell Biol. 22 (22): 8044–55. doi:10.1128/MCB.22.22.8044-8055.2002. PMC 134740. PMID 12391170.
  6. ^ Chong SS, Hu P, Hernandez N (Jun 2001). "Reconstitution of transcription from the human U6 small nuclear RNA promoter with eight recombinant polypeptides and a partially purified RNA polymerase III complex". J Biol Chem. 276 (23): 20727–34. doi:10.1074/jbc.M100088200. PMID 11279001.
  7. ^ a b "Entrez Gene: POLR3D polymerase (RNA) III (DNA directed) polypeptide D, 44kDa".

Further reading

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