Peptidyl-prolyl cis-trans isomerase-like 1 is an enzyme that in humans is encoded by the PPIL1 gene.[5][6][7]

PPIL1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesPPIL1, CYPL1, PPIase, hCyPX, CGI-124, peptidylprolyl isomerase like 1, PCH14
External IDsOMIM: 601301; MGI: 1916066; HomoloGene: 9367; GeneCards: PPIL1; OMA:PPIL1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_016059

NM_026845

RefSeq (protein)

NP_057143

NP_081121

Location (UCSC)Chr 6: 36.85 – 36.87 MbChr 17: 29.47 – 29.48 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

This gene is a member of the cyclophilin family of peptidylprolyl isomerases (PPIases). The cyclophilins are a highly conserved, ubiquitous family, members of which play an important role in protein folding, immunosuppression by cyclosporin A, and infection of HIV-1 virions.

Based on similarity to other PPIases, this protein could accelerate the folding of proteins and might catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.[7]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000137168Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000024007Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Mann SS, Pettenati MJ, von Kap-herr C, Hart TC (Mar 1999). "Reassignment of peptidyl prolyl isomerase-like 1 gene (PPIL1) to human chromosome region 6p21.1 by radiation hybrid mapping and fluorescence in situ hybridization". Cytogenet Cell Genet. 83 (3–4): 228–9. doi:10.1159/000015186. PMID 10072585. S2CID 85413695.
  6. ^ Ozaki K, Fujiwara T, Kawai A, Shimizu F, Takami S, Okuno S, Takeda S, Shimada Y, Nagata M, Watanabe T, Takaichi A, Takahashi E, Nakamura Y, Shin S (Jan 1997). "Cloning, expression and chromosomal mapping of a novel cyclophilin-related gene (PPIL1) from human fetal brain". Cytogenet Cell Genet. 72 (2–3): 242–5. doi:10.1159/000134199. PMID 8978786.
  7. ^ a b "Entrez Gene: PPIL1 peptidylprolyl isomerase (cyclophilin)-like 1".

Further reading

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