Diphosphoinositol pentakisphosphate kinase 2 is a protein that in humans is encoded by the PPIP5K2 gene. [5]

PPIP5K2
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesPPIP5K2, HISPPD1, IP7K2, VIP2, CFAP160, diphosphoinositol pentakisphosphate kinase 2, DFNB100
External IDsOMIM: 611648; MGI: 2142810; HomoloGene: 49409; GeneCards: PPIP5K2; OMA:PPIP5K2 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_173760

RefSeq (protein)
Location (UCSC)Chr 5: 103.12 – 103.21 MbChr 1: 97.71 – 97.77 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

edit

Inositol phosphates (IPs) and diphosphoinositol phosphates (PP-IPs), also known as inositol pyrophosphates, act as cell signaling molecules.

HISPPD1 has both IP6 kinase (EC 2.7.4.21) and PP-IP5 (also called IP7) kinase (EC 2.7.4.24) activities that produce the high-energy pyrophosphates PP-IP5 and PP2-IP4 (also called IP8), respectively (Fridy et al., 2007 [PubMed 17690096]).

References

edit
  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000145725Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000040648Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: Diphosphoinositol pentakisphosphate kinase 2". Retrieved 2017-03-21.

Further reading

edit

This article incorporates text from the United States National Library of Medicine, which is in the public domain.