PPM1F

Protein phosphatase 1F is an enzyme that in humans is encoded by the PPM1F gene.

PPM1F
Identifiers
Aliases	PPM1F, CAMKP, CaMKPase, FEM-2, POPX2, hFEM-2, protein phosphatase, Mg2+/Mn2+ dependent 1F
External IDs	MGI: 1918464; HomoloGene: 22828; GeneCards: PPM1F; OMA:PPM1F - orthologs
Gene location (Human) Chr. Chromosome 22 (human) Band 22q11.22 Start 21,919,425 bp End 21,952,848 bp
Gene location (Mouse) Chr. Chromosome 16 (mouse) Band 16|16 A3 Start 16,714,333 bp End 16,745,228 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in monocyte sural nerve granulocyte blood endothelial cell periodontal fiber spleen right lung tendon of biceps brachii apex of heart Top expressed in otic vesicle hand Epithelium of choroid plexus dentate gyrus of hippocampal formation granule cell central gray substance of midbrain right lung lobe carotid body otolith organ lens utricle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function phosphoprotein phosphatase activity calmodulin-dependent protein phosphatase activity metal ion binding protein binding catalytic activity cation binding hydrolase activity protein serine/threonine phosphatase activity protein tyrosine/serine/threonine phosphatase activity Cellular component perinuclear region of cytoplasm cytosol protein-containing complex Biological process apoptotic process peptidyl-threonine dephosphorylation negative regulation of protein kinase activity protein dephosphorylation positive regulation of epithelial cell migration positive regulation of growth intrinsic apoptotic signaling pathway positive regulation of gene expression positive regulation of chemotaxis negative regulation of protein kinase activity by regulation of protein phosphorylation negative regulation of peptidyl-serine phosphorylation positive regulation of focal adhesion assembly negative regulation of transcription, DNA-templated positive regulation of stress fiber assembly positive regulation of cell-substrate adhesion positive regulation of cysteine-type endopeptidase activity involved in apoptotic process positive regulation of cell migration negative regulation of protein transport peptidyl-serine dephosphorylation negative regulation of cell-cell adhesion mediated by cadherin Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9647 68606 Ensembl ENSG00000100034 ENSMUSG00000026181 UniProt P49593 Q8CGA0 RefSeq (mRNA) NM_014634 NM_176833 RefSeq (protein) NP_055449 NP_789803 Location (UCSC) Chr 22: 21.92 – 21.95 Mb Chr 16: 16.71 – 16.75 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase can interact with Rho guanine nucleotide exchange factors (PIX), and thus block the effects of p21-activated kinase 1 (PAK), a protein kinase mediating biological effects downstream of Rho GTPases. Calcium/calmodulin-dependent protein kinase II gamma (CAMK2G/CAMK-II) is found to be one of the substrates of this phosphatase. The overexpression of this phosphatase or CAMK2G has been shown to mediate caspase-dependent apoptosis. An alternatively spliced transcript variant has been identified, but its full-length nature has not been determined.

Further reading

• Nomura N, Miyajima N, Sazuka T, et al. (1995). "Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1". DNA Res. 1 (1): 27–35. doi:10.1093/dnares/1.1.27. PMID 7584026.
• Nomura N, Miyajima N, Sazuka T, et al. (1995). "Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1 (supplement)". DNA Res. 1 (1): 47–56. doi:10.1093/dnares/1.1.47. PMID 7584028.
• Kawasaki K, Minoshima S, Nakato E, et al. (1997). "One-megabase sequence analysis of the human immunoglobulin lambda gene locus". Genome Res. 7 (3): 250–61. doi:10.1101/gr.7.3.250. PMID 9074928.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Izmailova E, Bertley FM, Huang Q, et al. (2003). "HIV-1 Tat reprograms immature dendritic cells to express chemoattractants for activated T cells and macrophages". Nat. Med. 9 (2): 191–7. doi:10.1038/nm822. PMID 12539042. S2CID 26145639.
• Harvey BP, Banga SS, Ozer HL (2004). "Regulation of the multifunctional Ca2+/calmodulin-dependent protein kinase II by the PP2C phosphatase PPM1F in fibroblasts". J. Biol. Chem. 279 (23): 24889–98. doi:10.1074/jbc.M400656200. PMID 15140879.
• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.