PPP2R2D

PP2A subunit B isoform delta also known as serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform is a protein that in humans is encoded by the PPP2R2D gene. It is a regulatory subunit of the heterotrimeric protein phosphatase 2 enzyme.

PPP2R2D
Identifiers
Aliases	PPP2R2D, MDS026, protein phosphatase 2 regulatory subunit Bdelta, B55delta, B55D
External IDs	OMIM: 613992; MGI: 1289252; HomoloGene: 81915; GeneCards: PPP2R2D; OMA:PPP2R2D - orthologs
Gene location (Human) Chr. Chromosome 10 (human) Band 10q26.3 Start 131,901,008 bp End 131,959,834 bp
Gene location (Mouse) Chr. Chromosome 7 (mouse) Band 7 F4|7 82.95 cM Start 138,846,079 bp End 138,883,057 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in body of pancreas left ovary muscle of thigh cerebellar hemisphere right adrenal cortex right hemisphere of cerebellum left adrenal gland ganglionic eminence primary visual cortex left adrenal cortex Top expressed in internal carotid artery facial motor nucleus external carotid artery seminiferous tubule primitive streak endothelial cell of lymphatic vessel right ventricle spermatid brown adipose tissue motor neuron More reference expression data BioGPS n/a
Gene ontology Molecular function protein serine/threonine phosphatase activity protein binding protein phosphatase regulator activity Cellular component cytoplasm protein phosphatase type 2A complex cytosol Biological process cell division cell cycle exit from mitosis peptidyl-serine dephosphorylation mitotic cell cycle developmental process regulation of phosphoprotein phosphatase activity Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 55844 52432 Ensembl ENSG00000175470 ENSMUSG00000041769 UniProt Q66LE6 Q925E7 RefSeq (mRNA) NM_001003656 NM_001291310 NM_018461 NM_026391 NM_001347618 RefSeq (protein) NP_001278239 NP_060931 NP_001334547 NP_080667 Location (UCSC) Chr 10: 131.9 – 131.96 Mb Chr 7: 138.85 – 138.88 Mb PubMed search
Wikidata
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Further reading

• Batut J, Schmierer B, Cao J, Raftery LA, Hill CS, Howell M (September 2008). "Two highly related regulatory subunits of PP2A exert opposite effects on TGF-beta/Activin/Nodal signalling". Development. 135 (17): 2927–37. doi:10.1242/dev.020842. PMC 4940033. PMID 18697906.
• Chen HF, Lin LN, Chen YX, Wan JX, Luo J, Zhang CZ, Li XJ, Hu YM, Mai JR, Chen W, Lin ZN, Lin YC (2012). "Identification and functional analysis of variant haplotypes in the 5'-flanking region of protein phosphatase 2A-Bδ gene". PLOS ONE. 7 (4): e35524. Bibcode:2012PLoSO...735524C. doi:10.1371/journal.pone.0035524. PMC 3335092. PMID 22539979.