PRM1

Protamine 1 is a protein that in humans is encoded by the PRM1 gene.

PRM1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2AWR
Identifiers
Aliases	PRM1, CT94.1, P1, protamine 1
External IDs	OMIM: 182880; MGI: 97765; GeneCards: PRM1; OMA:PRM1 - orthologs
Gene location (Human) Chr. Chromosome 16 (human) Band 16p13.13 Start 11,280,841 bp End 11,281,330 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in sperm right testis left testis testicle caput epididymis tail of epididymis right coronary artery corpus epididymis ectocervix canal of the cervix n/a More reference expression data BioGPS n/a
Gene ontology Molecular function DNA binding Cellular component nucleosome nucleus nucleoplasm chromosome Biological process multicellular organism development spermatogenesis cell differentiation chromosome condensation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5619 19118 Ensembl ENSG00000175646 n/a UniProt P04553 P02319 RefSeq (mRNA) NM_002761 NM_013637 RefSeq (protein) NP_002752 NP_038665 Location (UCSC) Chr 16: 11.28 – 11.28 Mb n/a PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Further reading

• Tanaka H, Miyagawa Y, Tsujimura A, et al. (February 2003). "Single nucleotide polymorphisms in the protamine-1 and -2 genes of fertile and infertile human male populations". Molecular Human Reproduction. 9 (2): 69–73. doi:10.1093/molehr/gag010. PMID 12569175.
• Tanaka H, Miyagawa Y, Tsujimura A, et al. (February 2003). "Single nucleotide polymorphisms in the protamine-1 and -2 genes of fertile and infertile human male populations". Molecular Human Reproduction. 9 (2): 69–73. doi:10.1093/molehr/gag010. PMID 12569175.
• Aoki VW, Christensen GL, Atkins JF, et al. (November 2006). "Identification of novel polymorphisms in the nuclear protein genes and their relationship with human sperm protamine deficiency and severe male infertility". Fertility and Sterility. 86 (5): 1416–22. doi:10.1016/j.fertnstert.2006.04.033. PMID 16989827.
• Aoki VW, Christensen GL, Atkins JF, et al. (November 2006). "Identification of novel polymorphisms in the nuclear protein genes and their relationship with human sperm protamine deficiency and severe male infertility". Fertility and Sterility. 86 (5): 1416–22. doi:10.1016/j.fertnstert.2006.04.033. PMID 16989827.
• Aoki VW, Liu L, Jones KP, et al. (November 2006). "Sperm protamine 1/protamine 2 ratios are related to in vitro fertilization pregnancy rates and predictive of fertilization ability". Fertility and Sterility. 86 (5): 1408–15. doi:10.1016/j.fertnstert.2006.04.024. PMID 17011555.
• Ravel C, Chantot-Bastaraud S, El Houate B, et al. (July 2007). "Mutations in the protamine 1 gene associated with male infertility". Molecular Human Reproduction. 13 (7): 461–4. doi:10.1093/molehr/gam031. PMID 17494104.
• Depa-Martynów M, Kempisty B, Lianeri M, et al. (2007). "Association between fertilin beta, protamines 1 and 2 and spermatid-specific linker histone H1-like protein mRNA levels, fertilization ability of human spermatozoa, and quality of preimplantation embryos". Folia Histochemica et Cytobiologica. 45 (Suppl 1): S79-85. PMID 18292840.
• Kempisty B, Depa-Martynow M, Lianeri M, et al. (2007). "Evaluation of protamines 1 and 2 transcript contents in spermatozoa from asthenozoospermic men". Folia Histochemica et Cytobiologica. 45 (Suppl 1): S109-13. PMID 18292846.
• Hammoud S, Emery BR, Aoki VW, et al. (2007). "Identification of genetic variation in the 5' and 3' non-coding regions of the protamine genes in patients with protamine deregulation". Archives of Andrology. 53 (5): 267–74. doi:10.1080/01485010701569890. PMID 18309899. S2CID 1012898.