Brain-specific serine protease 4 (BSSP-4), also known as serine protease 22 or tryptase epsilon , is an enzyme that in humans is encoded by the PRSS22 gene .[ 5] [ 6] [ 7]
This gene encodes a member of the trypsin family of serine proteases. The enzyme is expressed in the airways in a developmentally regulated manner. The gene is part of a cluster of serine protease genes on chromosome 16.[ 5]
^ a b c ENSG00000282937 GRCh38: Ensembl release 89: ENSG00000005001, ENSG00000282937 – Ensembl , May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000045027 – Ensembl , May 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ a b "Entrez Gene: protease" .^ Wong GW, Yasuda S, Madhusudhan MS, Li L, Yang Y, Krilis SA, Sali A, Stevens RL (December 2001). "Human tryptase epsilon (PRSS22), a new member of the chromosome 16p13.3 family of human serine proteases expressed in airway epithelial cells" . J. Biol. Chem . 276 (52): 49169–82. doi :10.1074/jbc.M108677200 PMID 11602603 . ^ Yasuda S, Morokawa N, Wong GW, Rossi A, Madhusudhan MS, Sali A, Askew YS, Adachi R, Silverman GA, Krilis SA, Stevens RL (May 2005). "Urokinase-type plasminogen activator is a preferred substrate of the human epithelium serine protease tryptase epsilon/PRSS22" . Blood . 105 (10): 3893–901. doi :10.1182/blood-2003-10-3501 . PMC 1895090 PMID 15701722 .
Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment" . Genome Res . 13 (10): 2265–70. doi :10.1101/gr.1293003 . PMC 403697 PMID 12975309 . Martin J, Han C, Gordon LA, et al. (2004). "The sequence and analysis of duplication-rich human chromosome 16" . Nature . 432 (7020): 988–94. Bibcode :2004Natur.432..988M . doi :10.1038/nature03187 PMID 15616553 . Mitsui S, Okui A, Kominami K, et al. (2005). "A novel serine protease highly expressed in the pancreas is expressed in various kinds of cancer cells" . FEBS J . 272 (19): 4911–23. doi :10.1111/j.1742-4658.2005.04901.x PMID 16176265 . S2CID 25290079 . Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903. Bibcode :2002PNAS...9916899M . doi :10.1073/pnas.242603899 PMC 139241 PMID 12477932 . Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)" . Genome Res . 14 (10B): 2121–7. doi :10.1101/gr.2596504 . PMC 528928 PMID 15489334 .
