PTPRZ1

Receptor-type tyrosine-protein phosphatase zeta also known as phosphacan is an enzyme that in humans is encoded by the PTPRZ1 gene.

PTPRZ1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3JXF, 3S97, 5AWX
Identifiers
Aliases	PTPRZ1, HPTPZ, HPTPzeta, PTP-ZETA, PTP18, PTPRZ, PTPZ, R-PTP-zeta-2, RPTPB, RPTPbeta, phosphacan, protein tyrosine phosphatase, receptor type Z1, protein tyrosine phosphatase receptor type Z1
External IDs	OMIM: 176891; MGI: 97816; HomoloGene: 2136; GeneCards: PTPRZ1; OMA:PTPRZ1 - orthologs
Gene location (Human) Chr. Chromosome 7 (human) Band 7q31.32 Start 121,873,089 bp End 122,062,036 bp
Gene location (Mouse) Chr. Chromosome 6 (mouse) Band 6|6 A3.1 Start 22,875,501 bp End 23,052,915 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ventricular zone ganglionic eminence endothelial cell amygdala Region I of hippocampus proper optic nerve caudate nucleus nucleus accumbens corpus callosum external globus pallidus Top expressed in vestibular membrane of cochlear duct Rostral migratory stream mammillary body median eminence ventromedial nucleus lobe of cerebellum arcuate nucleus cerebellar vermis lateral septal nucleus anterior amygdaloid area More reference expression data BioGPS More reference expression data
Gene ontology Molecular function phosphoprotein phosphatase activity phosphatase activity protein binding protein tyrosine phosphatase activity transmembrane receptor protein tyrosine phosphatase activity hydrolase activity integrin binding Cellular component integral component of membrane membrane integral component of plasma membrane extracellular region perineuronal net intrinsic component of plasma membrane plasma membrane extracellular matrix synapse Biological process axonogenesis protein dephosphorylation oligodendrocyte differentiation regulation of oligodendrocyte progenitor proliferation central nervous system development hematopoietic progenitor cell differentiation learning or memory peptidyl-tyrosine dephosphorylation dephosphorylation cytokine-mediated signaling pathway regulation of myelination negative regulation of neuron apoptotic process positive regulation of oligodendrocyte differentiation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5803 19283 Ensembl ENSG00000106278 ENSMUSG00000068748 UniProt P23471 B9EKR1 RefSeq (mRNA) NM_001206838 NM_001206839 NM_002851 NM_001369395 NM_001369396 NM_001081306 NM_011219 NM_178180 NM_001311064 NM_001361349 RefSeq (protein) NP_001193767 NP_001193768 NP_002842 NP_001074775 NP_001297993 NP_001348278 NP_035349 NP_001389981 NP_001389982 NP_001389983 Location (UCSC) Chr 7: 121.87 – 122.06 Mb Chr 6: 22.88 – 23.05 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Function

This gene is a member of the receptor tyrosine phosphatase family and encodes a single-pass type I membrane protein with two cytoplasmic tyrosine-protein phosphatase domains, an alpha-carbonic anhydrase domain and a fibronectin type III domain. Alternative splice variants that encode different protein isoforms have been described but their full-length nature has not been determined.

Clinical significance

Expression of this gene is induced in gastric cancer cells, in the remyelinating oligodendrocytes of multiple sclerosis lesions, and in human embryonic kidney cells under hypoxic conditions. Both the protein and transcript are overexpressed in glioblastoma cells, promoting their haptotactic migration.

Further reading

• Krueger NX, Saito H (1992). "A human transmembrane protein-tyrosine-phosphatase, PTP zeta, is expressed in brain and has an N-terminal receptor domain homologous to carbonic anhydrases". Proc. Natl. Acad. Sci. U.S.A. 89 (16): 7417–21. Bibcode:1992PNAS...89.7417K. doi:10.1073/pnas.89.16.7417. PMC 49721. PMID 1323835.
• Kaplan R, Morse B, Huebner K, Croce C, Howk R, Ravera M, Ricca G, Jaye M, Schlessinger J (1990). "Cloning of three human tyrosine phosphatases reveals a multigene family of receptor-linked protein-tyrosine-phosphatases expressed in brain". Proc. Natl. Acad. Sci. U.S.A. 87 (18): 7000–4. Bibcode:1990PNAS...87.7000K. doi:10.1073/pnas.87.18.7000. PMC 54670. PMID 2169617.
• Krueger NX, Streuli M, Saito H (1990). "Structural diversity and evolution of human receptor-like protein tyrosine phosphatases". EMBO J. 9 (10): 3241–52. doi:10.1002/j.1460-2075.1990.tb07523.x. PMC 552056. PMID 2170109.
• Morton SM, Veile RA, Helms C, Lee M, Kuo WL, Gray J, Donis-Keller H (1998). "Subregional localization of 21 chromosome 7-specific expressed sequence tags (ESTs) by FISH using newly identified YACs and P1s". Genomics. 46 (3): 491–4. doi:10.1006/geno.1997.5051. PMID 9441757.
• Onyango P, Lubyova B, Gardellin P, Kurzbauer R, Weith A (1998). "Molecular cloning and expression analysis of five novel genes in chromosome 1p36". Genomics. 50 (2): 187–98. doi:10.1006/geno.1997.5186. PMID 9653645.
• Sanger Centre T, Washington University Genome Sequencing Cente T (1999). "Toward a complete human genome sequence". Genome Res. 8 (11): 1097–108. doi:10.1101/gr.8.11.1097. PMID 9847074.
• Maeda N, Ichihara-Tanaka K, Kimura T, Kadomatsu K, Muramatsu T, Noda M (1999). "A receptor-like protein-tyrosine phosphatase PTPzeta/RPTPbeta binds a heparin-binding growth factor midkine. Involvement of arginine 78 of midkine in the high affinity binding to PTPzeta". J. Biol. Chem. 274 (18): 12474–9. doi:10.1074/jbc.274.18.12474. PMID 10212223.
• Kawachi H, Tamura H, Watakabe I, Shintani T, Maeda N, Noda M (1999). "Protein tyrosine phosphatase zeta/RPTPbeta interacts with PSD-95/SAP90 family". Brain Res. Mol. Brain Res. 72 (1): 47–54. doi:10.1016/S0169-328X(99)00204-1. PMID 10521598.
• Meng K, Rodriguez-Peña A, Dimitrov T, Chen W, Yamin M, Noda M, Deuel TF (2000). "Pleiotrophin signals increased tyrosine phosphorylation of beta beta-catenin through inactivation of the intrinsic catalytic activity of the receptor-type protein tyrosine phosphatase beta/zeta". Proc. Natl. Acad. Sci. U.S.A. 97 (6): 2603–8. Bibcode:2000PNAS...97.2603M. doi:10.1073/pnas.020487997. PMC 15975. PMID 10706604.
• Kawachi H, Fujikawa A, Maeda N, Noda M (2001). "Identification of GIT1/Cat-1 as a substrate molecule of protein tyrosine phosphatase zeta /beta by the yeast substrate-trapping system". Proc. Natl. Acad. Sci. U.S.A. 98 (12): 6593–8. Bibcode:2001PNAS...98.6593K. doi:10.1073/pnas.041608698. PMC 34398. PMID 11381105.
• Thomaidou D, Coquillat D, Meintanis S, Noda M, Rougon G, Matsas R (2001). "Soluble forms of NCAM and F3 neuronal cell adhesion molecules promote Schwann cell migration: identification of protein tyrosine phosphatases zeta/beta as the putative F3 receptors on Schwann cells". J. Neurochem. 78 (4): 767–78. doi:10.1046/j.1471-4159.2001.00454.x. PMID 11520897. S2CID 24682985.
• Harroch S, Furtado GC, Brueck W, Rosenbluth J, Lafaille J, Chao M, Buxbaum JD, Schlessinger J (2002). "A critical role for the protein tyrosine phosphatase receptor type Z in functional recovery from demyelinating lesions". Nat. Genet. 32 (3): 411–4. doi:10.1038/ng1004. PMID 12355066. S2CID 19800079.
• Müller S, Kunkel P, Lamszus K, Ulbricht U, Lorente GA, Nelson AM, von Schack D, Chin DJ, Lohr SC, Westphal M, Melcher T (2003). "A role for receptor tyrosine phosphatase zeta in glioma cell migration". Oncogene. 22 (43): 6661–8. doi:10.1038/sj.onc.1206763. PMID 14555979.
• Bonora E, Lamb JA, Barnby G, Sykes N, Moberly T, Beyer KS, Klauck SM, Poustka F, Bacchelli E, Blasi F, Maestrini E, Battaglia A, Haracopos D, Pedersen L, Isager T, Eriksen G, Viskum B, Sorensen EU, Brondum-Nielsen K, Cotterill R, van Engeland H, de Jonge M, Kemner C, Steggehuis K, Scherpenisse M, Rutter M, Bolton PF, Parr JR, Poustka A, Bailey AJ, Monaco AP (2005). "Mutation screening and association analysis of six candidate genes for autism on chromosome 7q". Eur. J. Hum. Genet. 13 (2): 198–207. doi:10.1038/sj.ejhg.5201315. PMID 15523497.
• Polykratis A, Katsoris P, Courty J, Papadimitriou E (2005). "Characterization of heparin affin regulatory peptide signaling in human endothelial cells". J. Biol. Chem. 280 (23): 22454–61. doi:10.1074/jbc.M414407200. PMID 15797857.
• Wang V, Davis DA, Haque M, Huang LE, Yarchoan R (2005). "Differential gene up-regulation by hypoxia-inducible factor-1alpha and hypoxia-inducible factor-2alpha in HEK293T cells". Cancer Res. 65 (8): 3299–306. doi:10.1158/0008-5472.CAN-04-4130. PMID 15833863.
• Lu KV, Jong KA, Kim GY, Singh J, Dia EQ, Yoshimoto K, Wang MY, Cloughesy TF, Nelson SF, Mischel PS (2005). "Differential induction of glioblastoma migration and growth by two forms of pleiotrophin". J. Biol. Chem. 280 (29): 26953–64. doi:10.1074/jbc.M502614200. PMID 15908427.