Polymerase I and transcript release factor , also known as Cavin1 , Cavin-1 or PTRF , is a protein which in humans is encoded by the PTRF gene .[ 5] [ 6]
PTRF (Cavin1) forms trimers with Cavin2 and Cavin3 in caveola formation and has been shown to interact with other membrane associating proteins such as EHD2 and caveolins .[ 12]
PTRF has been shown to interact with ZNF148 .[ 13]
^ a b c GRCh38: Ensembl release 89: ENSG00000177469 – Ensembl , May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000004044 – Ensembl , May 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Entrez Gene: PTRF polymerase I and transcript release factor" .^ "CAVIN1 Symbol Report | HUGO Gene Nomenclature Committee" . www.genenames.org . Retrieved 2017-05-30 .^ Hill MM, Bastiani M, Luetterforst R, Kirkham M, Kirkham A, Nixon SJ, et al. (January 2008). "PTRF-Cavin, a conserved cytoplasmic protein required for caveola formation and function" . Cell . 132 (1): 113–124. doi :10.1016/j.cell.2007.11.042 . PMC 2265257 PMID 18191225 . ^ Qifti A, Balaji S, Scarlata S (June 2022). "Deformation of caveolae impacts global transcription and translation processes through relocalization of cavin-1" . The Journal of Biological Chemistry . 298 (6): 102005. doi :10.1016/j.jbc.2022.102005 PMC 9168624 PMID 35513070 . ^ Mason SW, Sander EE, Grummt I (January 1997). "Identification of a transcript release activity acting on ternary transcription complexes containing murine RNA polymerase I" . The EMBO Journal . 16 (1): 163–172. doi :10.1093/emboj/16.1.163 . PMC 1169623 PMID 9009277 . ^ Jansa P, Mason SW, Hoffmann-Rohrer U, Grummt I (May 1998). "Cloning and functional characterization of PTRF, a novel protein which induces dissociation of paused ternary transcription complexes" . The EMBO Journal . 17 (10): 2855–2864. doi :10.1093/emboj/17.10.2855 . PMC 1170626 PMID 9582279 . ^ Aboulaich N, Vainonen JP, Strålfors P, Vener AV (October 2004). "Vectorial proteomics reveal targeting, phosphorylation and specific fragmentation of polymerase I and transcript release factor (PTRF) at the surface of caveolae in human adipocytes" . The Biochemical Journal . 383 (Pt 2): 237–248. doi :10.1042/BJ20040647 . PMC 1134064 PMID 15242332 . ^ Kovtun O, Tillu VA, Ariotti N, Parton RG, Collins BM (April 2015). "Cavin family proteins and the assembly of caveolae" . Journal of Cell Science . 128 (7): 1269–1278. doi :10.1242/jcs.167866 . PMC 4379724 PMID 25829513 . ^ Hasegawa T, Takeuchi A, Miyaishi O, Xiao H, Mao J, Isobe K (April 2000). "PTRF (polymerase I and transcript-release factor) is tissue-specific and interacts with the BFCOL1 (binding factor of a type-I collagen promoter) zinc-finger transcription factor which binds to the two mouse type-I collagen gene promoters" . The Biochemical Journal . 347 Pt 1 (Pt 1): 55–59. doi :10.1042/0264-6021:3470055 . PMC 1220930 PMID 10727401 .
Jansa P, Mason SW, Hoffmann-Rohrer U, Grummt I (May 1998). "Cloning and functional characterization of PTRF, a novel protein which induces dissociation of paused ternary transcription complexes" . The EMBO Journal . 17 (10): 2855–2864. doi :10.1093/emboj/17.10.2855 . PMC 1170626 PMID 9582279 . Hasegawa T, Takeuchi A, Miyaishi O, Xiao H, Mao J, Isobe K (April 2000). "PTRF (polymerase I and transcript-release factor) is tissue-specific and interacts with the BFCOL1 (binding factor of a type-I collagen promoter) zinc-finger transcription factor which binds to the two mouse type-I collagen gene promoters" . The Biochemical Journal . 347 Pt 1 (Pt 1): 55–59. doi :10.1042/0264-6021:3470055 . PMC 1220930 PMID 10727401 . Aboulaich N, Vainonen JP, Strålfors P, Vener AV (October 2004). "Vectorial proteomics reveal targeting, phosphorylation and specific fragmentation of polymerase I and transcript release factor (PTRF) at the surface of caveolae in human adipocytes" . The Biochemical Journal . 383 (Pt 2): 237–248. doi :10.1042/BJ20040647 . PMC 1134064 PMID 15242332 . Rush J, Moritz A, Lee KA, Guo A, Goss VL, Spek EJ, et al. (January 2005). "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells". Nature Biotechnology . 23 (1): 94–101. doi :10.1038/nbt1046 . PMID 15592455 . S2CID 7200157 . Zhang Y, Wolf-Yadlin A, Ross PL, Pappin DJ, Rush J, Lauffenburger DA, White FM (September 2005). "Time-resolved mass spectrometry of tyrosine phosphorylation sites in the epidermal growth factor receptor signaling network reveals dynamic modules" . Molecular & Cellular Proteomics . 4 (9): 1240–1250. doi :10.1074/mcp.M500089-MCP200 PMID 15951569 . Aboulaich N, Ortegren U, Vener AV, Strålfors P (November 2006). "Association and insulin regulated translocation of hormone-sensitive lipase with PTRF". Biochemical and Biophysical Research Communications . 350 (3): 657–661. doi :10.1016/j.bbrc.2006.09.094 . PMID 17026959 . Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (November 2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks" . Cell . 127 (3): 635–648. doi :10.1016/j.cell.2006.09.026 PMID 17081983 . S2CID 7827573 .
