Palazzo De Felice is a fortified baroque palace built into a medieval castle in Rosciano, Province of Pescara (Abruzzo).
Palazzo De Felice may also refer to:
- Palazzo De Felice, Grottaglie, a palace in Grottaglie, Province of Taranto, in Apulia.
- Palazzo De Felice, Somma Vesuviana, a palace in Somma Vesuviana, Province of Napoli, in Campania.