Palepoi is a Samoan surname. Notable people with the surname include:

  • Anton Palepoi (born 1978), American football player, brother of Tenny Palepoi
  • Opeta Palepoi (born 1975), Samoan rugby union player
  • Tenny Palepoi (born 1990), American football player, brother of Anton Palepoi
  • Mauga Palepoi (died 1963), American Samoan politician