Pamapimod is an investigational drug which is being evaluated for the treatment of autoimmune diseases. It is a p38 mitogen-activated protein kinase inhibitor.[1] It has been evaluated in a phase 2 clinical trial for the treatment of rheumatoid arthritis, but was found not to be effective.[2][3] It has subsequently been investigated as a possible treatment for osteoarthritis.[4][5]
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Formula | C19H20F2N4O4 |
Molar mass | 406.390 g·mol−1 |
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editReferences
edit- ^ Hill RJ, Dabbagh K, Phippard D, Li C, Suttmann RT, Welch M, et al. (December 2008). "Pamapimod, a novel p38 mitogen-activated protein kinase inhibitor: preclinical analysis of efficacy and selectivity". The Journal of Pharmacology and Experimental Therapeutics. 327 (3): 610–9. doi:10.1124/jpet.108.139006. PMID 18776065.
- ^ Cohen S, Fleischmann R (May 2010). "Kinase inhibitors: a new approach to rheumatoid arthritis treatment". Current Opinion in Rheumatology. 22 (3): 330–5. doi:10.1097/BOR.0b013e3283378e6f. PMID 20164774.
- ^ Cohen SB, Cheng TT, Chindalore V, Damjanov N, Burgos-Vargas R, Delora P, et al. (February 2009). "Evaluation of the efficacy and safety of pamapimod, a p38 MAP kinase inhibitor, in a double-blind, methotrexate-controlled study of patients with active rheumatoid arthritis". Arthritis and Rheumatism. 60 (2): 335–344. doi:10.1002/art.24266. PMID 19180516.
- ^ Zhao X, Ning L, Xie Z, Jie Z, Li X, Wan X, et al. (May 2019). "The Novel p38 Inhibitor, Pamapimod, Inhibits Osteoclastogenesis and Counteracts Estrogen-Dependent Bone Loss in Mice". Journal of Bone and Mineral Research. 34 (5): 911–922. doi:10.1002/jbmr.3655. PMID 30615802.
- ^ Zhang J, Yan C, He W, Wang M, Liu J (December 2020). "Inhibition against p38/MEF2C pathway by Pamapimod protects osteoarthritis chondrocytes hypertrophy". Panminerva Medica. doi:10.23736/S0031-0808.20.04170-1. PMID 33263251.