Panaca may refer to:
- In the United States
- Panaca, Nevada, an unincorporated town in Lincoln County
- Panaca Summit Archeological District, near the above community
- Panaca Formation, a geologic formation in Nevada
- Elsewhere
- PANACA, or (Spanish: Parque Nacional De La Cultura Agropecuaria), a Colombian theme park
- Panaca Palace, a palatial residence in the Portuguese capital of Lisbon
- Panaca or panaka, in Inca culture, a family formed by all the descendants of a monarch