Papadimitriou or Papademetriou (Greek: Παπαδημητρίου) is a Greek surname that may refer to:
- Thodoros Papadimitriou (1931–2018), Greek sculptor
- Dimitri B. Papadimitriou (born 1946), Greek economist
- Christos Papadimitriou (born 1949), Greek computer scientist
- Babis Papadimitriou (born 1954), Greek journalist, news analyst, economist and commentator
- Nicholas Papademetriou, Australian actor of Greek Cypriot descent
- Lisa Papademetriou (born 1971), American author of young adult fiction
- Alexandros Papadimitriou (born 1973), Greek Olympic hammer thrower
- Justin Peter Papadimitriou (born 1977), Canadian drummer
- Aristomenis Papadimitriou (born 1984), Greek-American historian
- Lefteris Papadimitriou, Greek composer