Papalia (Italian pronunciation: [papaˈliːa]) is an Italian surname, and may refer to:
- Adam Papalia, Australian sportscaster
- Anna Papalia, American author
- Carmen Papalia, Canadian artist
- Melanie Papalia, Canadian actress
- Paul Papalia, Australian politician
- The Papalia crime family, an Italian-Canadian crime family
- Johnny Papalia, Canadian mobster