Pastore is a surname. Notable people with the surname include:
- Ada I. Pastore (1906–1952), Argentine botanist, curator, teacher, and explorer
- Affonso Celso Pastore (born 1939), Brazilian economist and former president of the Brazilian Central Bank
- Aldo Pastore (1930 – 2022), Italian politician
- Annalisa Pastore, Professor of Chemistry and Molecular Biology at King's College London
- Andrea Pastore (born 1994), Italian professional footballer
- Donna Pastore (contemporary), American professor; past president of the National Association for Girls and Women in Sport
- Frank Pastore (1957 – 2012), American Major League Baseball player and radio host
- Felice Pastore (1786–1862), Italian nobleman
- Garry Pastore (born 1961), American actor, stuntman, writer, and filmmaker
- Girolamo Pastore (late 19th century), Italian painter
- Gianpiero Pastore (born 1976), Italian fencer and Olympic medal winner
- Javier Pastore (born 1989), Argentine professional association football player
- Joaquin Pastore (born 1981), Uruguayan rugby union player
- John Pastore (1907–2000), American lawyer and politician
- Louis Pastore (1931–2020), American politician and businessman
- Luigi Pastore (1834–1913), Italian painter
- Mauro Pastore (born 1967), Italian designer
- Nick Pastore (contemporary), American law enforcement officer from New Haven, Connecticut
- Pietro Pastore (1903 – 1968), Italian professional footballer
- Pierfranco Pastore (1927–2015), Roman Catholic bishop.
- Ralph T. Pastore, historian and archaeologist
- Rodrigo Pastore (born 1972), Argentine basketball coach and former player
- Sergio Pastore (1932-1987), Italian director and screenwriter
- Tony Pastore (born 1966), former Australian rules footballer
- Valentino Annibale Pastore (1868-1956), Italian philosopher and logician
- Vincent Pastore (born 1946), American film and television actor