Pentalenic acid synthase

Pentalenic acid synthase (EC 1.14.15.11, CYP105D7, sav7469 (gene)) is an enzyme with systematic name 1-deoxypentalenate,reduced ferredoxin:O2 oxidoreductase.[1] This enzyme catalyses the following chemical reaction

Pentalenic acid synthase
Identifiers
EC no.1.14.15.11
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Search
PMCarticles
PubMedarticles
NCBIproteins
1-deoxypentalenate + reduced ferredoxin + O2 pentalenate + oxidized ferredoxin + H2O

Pentalenic acid synthase is a heme-thiolate enzyme (P-450).

References

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  1. ^ Takamatsu S, Xu LH, Fushinobu S, Shoun H, Komatsu M, Cane DE, Ikeda H (January 2011). "Pentalenic acid is a shunt metabolite in the biosynthesis of the pentalenolactone family of metabolites: hydroxylation of 1-deoxypentalenic acid mediated by CYP105D7 (SAV_7469) of Streptomyces avermitilis". The Journal of Antibiotics. 64 (1): 65–71. doi:10.1038/ja.2010.135. PMC 3030646. PMID 21081950.
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