Pentalenolactone synthase (EC 1.14.19.8, Formerly EC 1.3.7.10, penM (gene), pntM (gene)) is an enzyme with systematic name pentalenolactone-F:oxidized-ferredoxin oxidoreductase (pentalenolactone forming).[1] This enzyme catalyse the following chemical reaction
| Pentalenolactone synthase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 1.14.19.8 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
- pentalenolactone F + oxidized ferredoxin pentalenolactone + reduced ferredoxin
This is heme-thiolate protein (P-450), which is isolated from the bacteria Streptomyces exfoliatus and Streptomyces arenae.
References
edit- ^ Zhu D, Seo MJ, Ikeda H, Cane DE (February 2011). "Genome mining in streptomyces. Discovery of an unprecedented P450-catalyzed oxidative rearrangement that is the final step in the biosynthesis of pentalenolactone". Journal of the American Chemical Society. 133 (7): 2128–31. doi:10.1021/ja111279h. PMC 3041837. PMID 21284395.
External links
edit- Pentalenolactone+synthase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
