Pernell may refer to:
Given name:
- Pernell Davis (born 1976), American football defensive tackle
- Pernell McPhee (born 1988), American football linebacker
- Pernell Roberts (1928–2010), American stage, movie and television actor
- Pernell Saturnino, Grammy Award winner percussionist from Curaçao
- Pernell Whitaker (1964–2019), American professional boxing trainer
- Pernell (healer) (floruit 1350), English healer
Surname:
- Geoffrey Pernell, murderer of Louise Jensen in 1994 in Cyprus
- Lia Pernell (born 1981), American rower
- Ruby Pernell (1917–2001), professor of social work at the University of Minnesota
Places:
- Pernell, Oklahoma, unincorporated community in Garvin County, Oklahoma, United States