This family represents the internal ribosome entry site (IRES) of the pestiviruses. The pestivirus IRES allows cap and end-independent translation of mRNA in the host cell. The IRES achieves this by mediating the internal initiation of translation by recruiting a ribosomal 43S pre-initiation complex directly to the initiation codon and eliminates the requirement for the eukaryotic initiation factor, eIF4F.[1] The classical swine fever virus UTR described appears to be longer at the 5' end than other pestivirus UTRs.[1] This family represents the conserved core.
| Pestivirus internal ribosome entry site (IRES) | |
|---|---|
 Predicted secondary structure and sequence conservation of IRES_Pesti | |
| Identifiers | |
| Symbol | IRES_Pesti |
| Alt. Symbols | Pesti_IRES |
| Rfam | RF00209 |
| Other data | |
| RNA type | Cis-reg; IRES |
| Domain(s) | Viruses |
| GO | GO:0043022 |
| SO | SO:0000243 |
| PDB structures | PDBe |
References
edit- ^ a b Kolupaeva VG, Pestova TV, Hellen CU (December 2000). "Ribosomal binding to the internal ribosomal entry site of classical swine fever virus". RNA. 6 (12): 1791–1807. doi:10.1017/S1355838200000662. PMC 1370049. PMID 11142379.
External links
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