Phenylaminotetralin

Phenylaminotetralin
Names
	IUPAC name (2S,4R)-N,N-dimethyl-4-phenyl-1,2,3,4-tetrahydronaphthalen-2-amine
Identifiers
3D model (JSmol)	Interactive image;
ChemSpider	8281741;
PubChem CID	69080096;
	InChI InChI=1S/C18H21N/c1-19(2)16-12-15-10-6-7-11-17(15)18(13-16)14-8-4-3-5-9-14/h3-11,16,18H,12-13H2,1-2H3/t16-,18-/m1/s1 Key: DXJUCAUQIHNOAF-SJLPKXTDSA-N; InChI=1S/C18H21N/c1-19(2)16-12-15-10-6-7-11-17(15)18(13-16)14-8-4-3-5-9-14/h3-11,16,18H,12-13H2,1-2H3/t16-,18-/m1/s1 Key: DXJUCAUQIHNOAF-SJLPKXTDSA-N;
	SMILES CN(C)[C@H]1CC(C2=CC=CC=C2C1)C3=CC=CC=C3;
Properties
Chemical formula	C18H21N
Molar mass	251.373 g·mol−1
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). Infobox references

Phenylaminotetralins are novel histamine receptor ligands. Binding assays determined that (-)-trans-H₂-PAT possessed the strongest binding affinity at the histamine H₁ receptor.^[1]

References

^ Booth, RG; Moniri, NH; Bakker, RA; Choksi, NY; Nix, WB; Timmerman, H; Leurs, R (July 2002). "A novel phenylaminotetralin radioligand reveals a subpopulation of histamine H(1) receptors". The Journal of Pharmacology and Experimental Therapeutics. 302 (1): 328–36. doi:10.1124/jpet.302.1.328. PMID 12065734.

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[1] Booth, RG; Moniri, NH; Bakker, RA; Choksi, NY; Nix, WB; Timmerman, H; Leurs, R (July 2002). "A novel phenylaminotetralin radioligand reveals a subpopulation of histamine H(1) receptors". The Journal of Pharmacology and Experimental Therapeutics. 302 (1): 328–36. doi:10.1124/jpet.302.1.328. PMID 12065734.

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