Phi Sigma Beta (ΦΣΒ) may refer to:
- Phi Sigma Beta (Puerto Rico), a former "zone" or country district of US chapters of Phi Sigma Alpha, a Puerto Rican-based fraternity
- Tau Delta Phi, a high school fraternity for American Jewish boys, formed June 22, 1910 as Phi Sigma Beta, which was reestablished as the collegiate fraternity Tau Delta Phi in 1914.
- Phi Sigma Gamma, a professional fraternity for osteopathic medicine formed under the name Phi Sigma Beta prior to 1915, which merged with Phi Omega Gamma to form Phi Sigma Gamma by 1916.
- Phi Sigma Beta, a dormant general women's sorority formed at Pace University in 1951, which in the 1990s had created three additional chapters. Some of its chapters survived into the 2000s.