Phi Sigma Chi (ΦΣΧ) may refer to:
- Phi Sigma Chi (sorority), an over 100-year old local sorority formed in 1924 at Grove City College in Grove City, PA
- Phi Sigma Chi (fraternity), a 13-chapter multicultural fraternity founded on November 16, 1996 at the New York City College of Technology, (CUNY)
- Phi Sigma Chi (Defiance), a local fraternity formed in 1967 at Defiance College in Defiance, OH, which became the Ohio Omicron chapter of Sigma Phi Epsilon (ΣΦΕ) on April 4, 1970
- Phi Sigma Chi (Trine), a local fraternity formed in 1927 at Trine University in Angola, IN, which had several fraternal affiliations before becoming the Indiana Theta chapter of Sigma Phi Epsilon (ΣΦΕ) on May 4, 1968
- Phi Sigma Chi (secondary), a dormant high school fraternity founded on November 28, 1900 in Zanesville, OH, estimated to have chartered 117 chapters
This disambiguation page lists articles associated with the title Phi Sigma Chi.
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