In enzymology, a phloretin hydrolase (EC 3.7.1.4) is an enzyme that catalyzes the chemical reaction
| phloretin hydrolase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 3.7.1.4 | ||||||||
| CAS no. | 37289-38-6 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
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- phloretin + H2O phloretate + phloroglucinol
Thus, the two substrates of this enzyme are phloretin and H2O, whereas its two products are phloretate and phloroglucinol.
This enzyme belongs to the family of hydrolases, specifically those acting on carbon–carbon bonds in ketonic substances. The systematic name of this enzyme class is 2',4,4',6'-tetrahydroxydehydrochalcone 1,3,5-trihydroxybenzenehydrolase. This enzyme is also called lactase-phlorizin hydrolase.
References
edit- Minamikawa T, Jayasankar NP, Bohm BA, Taylor IE, Towers GH (1970). "An inducible hydrolase from Aspergillus niger, acting on carbon-carbon bonds, for phlorrhizin and other C-acylated phenols". Biochem. J. 116 (5): 889–97. PMC 1185512. PMID 5441377.
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