Phloroisovalerophenone synthase

In enzymology, a phloroisovalerophenone synthase (EC 2.3.1.156) is an enzyme that catalyzes the chemical reaction

phloroisovalerophenone synthase
Identifiers
EC no.2.3.1.156
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO
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PMCarticles
PubMedarticles
NCBIproteins
isovaleryl-CoA + 3 malonyl-CoA 4 CoASH + 3 CO2 + 3-methyl-1-(2,4,6-trihydroxyphenyl)butan-1-one

Thus, the two substrates of this enzyme are isovaleryl-CoA and malonyl-CoA, whereas its 3 products are CoASH, CO2, and 3-methyl-1-(2,4,6-trihydroxyphenyl)butan-1-one.

This enzyme belongs to the family of transferases, specifically those acyltransferases transferring groups other than aminoacyl groups. The systematic name of this enzyme class is isovaleryl-CoA:malonyl-CoA acyltransferase. Other names in common use include valerophenone synthase, and 3-methyl-1-(trihydroxyphenyl)butan-1-one synthase.

References

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  • Verpoorte R (1997). "Enzymes from the biosynthesis of hop alpha and beta acids". Proc. 26th Congr. Eur. Brew. Conv.: 215–221.
  • Zuurbier KW, Leser J, Berger T, Hofte AJ, Schröder G, Verpoorte R, Schröder J (December 1998). "4-Hydroxy-2-pyrone formation by chalcone and stilbene synthase with nonphysiological substrates". Phytochemistry. 49 (7): 1945–51. doi:10.1016/S0031-9422(98)00346-X. PMID 9883590.