In enzymology, a phosphatidylcholine synthase (EC 2.7.8.24) is an enzyme that catalyzes the chemical reaction
| phosphatidylcholine synthase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 2.7.8.24 | ||||||||
| CAS no. | 243666-86-6 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
- CDP-diacylglycerol + choline CMP + phosphatidylcholine
Thus, the two substrates of this enzyme are CDP-diacylglycerol and choline, whereas its two products are CMP and phosphatidylcholine.
This enzyme belongs to the family of transferases, specifically those transferring non-standard substituted phosphate groups. The systematic name of this enzyme class is CDP-diacylglycerol:choline O-phosphatidyltransferase. This enzyme is also called CDP-diglyceride-choline O-phosphatidyltransferase. This enzyme participates in glycerophospholipid metabolism.
References
edit- de Rudder KE, Sohlenkamp C, Geiger O (1999). "Plant-exuded choline is used for rhizobial membrane lipid biosynthesis by phosphatidylcholine synthase". J. Biol. Chem. 274 (28): 20011–6. doi:10.1074/jbc.274.28.20011. PMID 10391951.
- Sohlenkamp C, de Rudder KE, Rohrs V, Lopez-Lara IM, Geiger O (2000). "Cloning and characterization of the gene for phosphatidylcholine synthase". J. Biol. Chem. 275 (25): 18919–25. doi:10.1074/jbc.M000844200. PMID 10858449.
