Phospholipase A2 group IVD is a protein that in humans is encoded by the PLA2G4D gene. [5]
Function
editThe phospholipase A2 enzyme family, including PLA2G4D, catalyze the hydrolysis of glycerophospholipids at the sn-2 position and then liberate free fatty acids and lysophospholipids.[6]
References
edit- ^ a b c GRCh38: Ensembl release 89: ENSG00000159337 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000070719 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Entrez Gene: Phospholipase A2 group IVD". Retrieved 2017-09-13.
- ^ Chiba, H; Michibata, H; Wakimoto, K; Seishima, M; Kawasaki, S; Okubo, K; Mitsui, H; Torii, H; Imai, Y (2004). "Cloning of a gene for a novel epithelium-specific cytosolic phospholipase A2, cPLA2delta, induced in psoriatic skin". Journal of Biological Chemistry. 279 (13): 12890–7. doi:10.1074/jbc.M305801200. PMID 14709560.
Further reading
edit- Chiba H, Michibata H, Wakimoto K, Seishima M, Kawasaki S, Okubo K, Mitsui H, Torii H, Imai Y (2004). "Cloning of a gene for a novel epithelium-specific cytosolic phospholipase A2, cPLA2delta, induced in psoriatic skin". J. Biol. Chem. 279 (13): 12890–7. doi:10.1074/jbc.M305801200. PMID 14709560.
- Tao R, Yu Y, Zhang X, Shi J, Guo Y, Wang C, Han B, Xu Q, Shang H, Zhang X, Xie L, Liu S, Ju G, Shen Y, Wei J (2005). "A family based study of the genetic association between the PLA2G4D gene and schizophrenia". Prostaglandins Leukot. Essent. Fatty Acids. 73 (6): 419–22. doi:10.1016/j.plefa.2005.08.008. PMID 16213696.
- Yu Q, Shi JP, Kou CG, Meng XF, Yu YQ (2008). "[Study on the genetic association between the polymorphism of cytosolic phospholipase A2 family genes and schizophrenia]". Zhonghua Liu Xing Bing Xue Za Zhi (in Chinese). 29 (2): 173–6. PMID 18686860.
- Talmud PJ, Drenos F, Shah S, Shah T, Palmen J, Verzilli C, Gaunt TR, Pallas J, Lovering R, Li K, Casas JP, Sofat R, Kumari M, Rodriguez S, Johnson T, Newhouse SJ, Dominiczak A, Samani NJ, Caulfield M, Sever P, Stanton A, Shields DC, Padmanabhan S, Melander O, Hastie C, Delles C, Ebrahim S, Marmot MG, Smith GD, Lawlor DA, Munroe PB, Day IN, Kivimaki M, Whittaker J, Humphries SE, Hingorani AD (2009). "Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip". Am. J. Hum. Genet. 85 (5): 628–42. doi:10.1016/j.ajhg.2009.10.014. PMC 2775832. PMID 19913121.
- Bailey SD, Xie C, Do R, Montpetit A, Diaz R, Mohan V, Keavney B, Yusuf S, Gerstein HC, Engert JC, Anand S (2010). "Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study". Diabetes Care. 33 (10): 2250–3. doi:10.2337/dc10-0452. PMC 2945168. PMID 20628086.
- Parry M, Rose-Zerilli MJ, Gibson J, Ennis S, Walewska R, Forster J, Parker H, Davis Z, Gardiner A, Collins A, Oscier DG, Strefford JC (2013). "Whole exome sequencing identifies novel recurrently mutated genes in patients with splenic marginal zone lymphoma". PLOS ONE. 8 (12): e83244. Bibcode:2013PLoSO...883244P. doi:10.1371/journal.pone.0083244. PMC 3862727. PMID 24349473.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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