Phospholysine phosphohistidine inorganic pyrophosphate phosphatase

Phospholysine phosphohistidine inorganic pyrophosphate phosphatase is a protein that in humans is encoded by the LHPP gene.

LHPP
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2X4D
Identifiers
Aliases	LHPP, HDHD2B, phospholysine phosphohistidine inorganic pyrophosphate phosphatase
External IDs	OMIM: 617231; MGI: 1923679; HomoloGene: 41469; GeneCards: LHPP; OMA:LHPP - orthologs
Gene location (Human) Chr. Chromosome 10 (human) Band 10q26.13 Start 124,461,823 bp End 124,617,888 bp
Gene location (Mouse) Chr. Chromosome 7 (mouse) Band 7|7 F3 Start 132,212,367 bp End 132,308,149 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in C1 segment olfactory bulb tibial nerve inferior olivary nucleus dorsal motor nucleus of vagus nerve hypothalamus amygdala anterior cingulate cortex substantia nigra putamen Top expressed in lip left lobe of liver tail of embryo crypt of lieberkuhn of small intestine internal carotid artery external carotid artery primitive streak muscle of thigh dentate gyrus of hippocampal formation granule cell primary oocyte More reference expression data BioGPS n/a
Gene ontology Molecular function hydrolase activity protein homodimerization activity Inorganic pyrophosphatase magnesium ion binding metal ion binding phosphatase activity protein histidine phosphatase activity Cellular component cytosol nucleus cytoplasm nuclear speck Biological process phosphate-containing compound metabolic process purine ribonucleoside monophosphate biosynthetic process protein dephosphorylation dephosphorylation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 64077 76429 Ensembl ENSG00000107902 ENSMUSG00000030946 UniProt Q9H008 Q9D7I5 RefSeq (mRNA) NM_001167880 NM_022126 NM_001318331 NM_001318332 NM_029609 RefSeq (protein) NP_001161352 NP_001305260 NP_001305261 NP_071409 NP_083885 Location (UCSC) Chr 10: 124.46 – 124.62 Mb Chr 7: 132.21 – 132.31 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Further reading

• Grupe A, Li Y, Rowland C, Nowotny P, Hinrichs AL, Smemo S, Kauwe JS, Maxwell TJ, Cherny S, Doil L, Tacey K, van Luchene R, Myers A, Wavrant-De Vrièze F, Kaleem M, Hollingworth P, Jehu L, Foy C, Archer N, Hamilton G, Holmans P, Morris CM, Catanese J, Sninsky J, White TJ, Powell J, Hardy J, O'Donovan M, Lovestone S, Jones L, Morris JC, Thal L, Owen M, Williams J, Goate A (January 2006). "A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease". Am. J. Hum. Genet. 78 (1): 78–88. doi:10.1086/498851. PMC 1380225. PMID 16385451.
• Neff CD, Abkevich V, Packer JC, Chen Y, Potter J, Riley R, Davenport C, DeGrado Warren J, Jammulapati S, Bhathena A, Choi WS, Kroeger PE, Metzger RE, Gutin A, Skolnick MH, Shattuck D, Katz DA (June 2009). "Evidence for HTR1A and LHPP as interacting genetic risk factors in major depression". Mol. Psychiatry. 14 (6): 621–30. doi:10.1038/mp.2008.8. PMID 18268499.
• Neff CD, Abkevich V, Packer JC, Chen Y, Potter J, Riley R, Davenport C, DeGrado Warren J, Jammulapati S, Bhathena A, Choi WS, Kroeger PE, Metzger RE, Gutin A, Skolnick MH, Shattuck D, Katz DA (June 2009). "Evidence for HTR1A and LHPP as interacting genetic risk factors in major depression". Mol. Psychiatry. 14 (6): 621–30. doi:10.1038/mp.2008.8. PMID 18268499.
• Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR (2010). "Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score". Mol. Med. 16 (7–8): 247–53. doi:10.2119/molmed.2009.00159. PMC 2896464. PMID 20379614.
• Polimanti R, Wang Q, Meda SA, Patel KT, Pearlson GD, Zhao H, Farrer LA, Kranzler HR, Gelernter J (February 2017). "The Interplay Between Risky Sexual Behaviors and Alcohol Dependence: Genome-Wide Association and Neuroimaging Support for LHPP as a Risk Gene". Neuropsychopharmacology. 42 (3): 598–605. doi:10.1038/npp.2016.153. PMC 5240175. PMID 27531626.
• Lesseur C, Diergaarde B, Olshan AF, Wünsch-Filho V, Ness AR, Liu G, Lacko M, Eluf-Neto J, Franceschi S, Lagiou P, Macfarlane GJ, Richiardi L, Boccia S, Polesel J, Kjaerheim K, Zaridze D, Johansson M, Menezes AM, Curado MP, Robinson M, Ahrens W, Canova C, Znaor A, Castellsagué X, Conway DI, Holcátová I, Mates D, Vilensky M, Healy CM, Szeszenia-Dąbrowska N, Fabiánová E, Lissowska J, Grandis JR, Weissler MC, Tajara EH, Nunes FD, de Carvalho MB, Thomas S, Hung RJ, Peters WH, Herrero R, Cadoni G, Bueno-de-Mesquita HB, Steffen A, Agudo A, Shangina O, Xiao X, Gaborieau V, Chabrier A, Anantharaman D, Boffetta P, Amos CI, McKay JD, Brennan P (December 2016). "Genome-wide association analyses identify new susceptibility loci for oral cavity and pharyngeal cancer". Nat. Genet. 48 (12): 1544–1550. doi:10.1038/ng.3685. PMC 5131845. PMID 27749845.