Phosphonoacetaldehyde reductase (NADH) (EC 1.1.1.309, PhpC) is an enzyme with systematic name 2-hydroxyethylphosphonate:NAD+ oxidoreductase.[1] This enzyme catalyses the following chemical reaction
| Phosphonoacetaldehyde reductase (NADH) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 1.1.1.309 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
- 2-hydroxyethylphosphonate + NAD+ phosphonoacetaldehyde + NADH + H+
The enzyme from Streptomyces viridochromogenes catalyses a step in the biosynthesis of phosphinothricin tripeptide, the reduction of phosphonoacetaldehyde to 2-hydroxyethylphosphonate.
References
edit- ^ Blodgett JA, Thomas PM, Li G, Velasquez JE, van der Donk WA, Kelleher NL, Metcalf WW (August 2007). "Unusual transformations in the biosynthesis of the antibiotic phosphinothricin tripeptide". Nature Chemical Biology. 3 (8): 480–5. doi:10.1038/nchembio.2007.9. PMC 4313788. PMID 17632514.
External links
edit- Phosphonoacetaldehyde+reductase+(NADH) at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
