The enzyme phosphopantothenoylcysteine decarboxylase (EC 4.1.1.36) catalyzes the chemical reaction
| phosphopantothenoylcysteine decarboxylase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 4.1.1.36 | ||||||||
| CAS no. | 9024-69-5 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
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- N-[(R)-4'-phosphopantothenoyl]-L-cysteine pantotheine 4'-phosphate + CO2
This enzyme belongs to the family of lyases, to be specific the carboxy-lyases, which cleave carbon-carbon bonds. The systematic name of this enzyme class is N-[(R)-4'-phosphopantothenoyl]-L-cysteine carboxy-lyase (pantotheine-4'-phosphate-forming). This enzyme participates in coenzyme A (CoA) biosynthesis from pantothenic acid.
Structural studies
editAs of late 2007, 3 structures have been solved for this class of enzymes, with PDB accession codes 1MVL, 1MVN, and 1QZU.
References
edit- Brown GM (1958). "Requirement of cytidine triphosphate for the biosynthesis of phosphopantetheine". J. Am. Chem. Soc. 80 (12): 3161. doi:10.1021/ja01545a062.
- Brown GM (February 1959). "The metabolism of pantothenic acid". The Journal of Biological Chemistry. 234 (2): 370–8. doi:10.1016/S0021-9258(18)70307-4. PMID 13630913.
