Phosphotyrosine interaction domain containing 1

Phosphotyrosine interaction domain containing 1 is a protein that in humans is encoded by the PID1 gene.

PID1
Identifiers
Aliases	PID1, NYGGF4, P-CLI1, PCLI1, HMFN2073, phosphotyrosine interaction domain containing 1
External IDs	OMIM: 612930; MGI: 2138391; HomoloGene: 9924; GeneCards: PID1; OMA:PID1 - orthologs
Gene location (Human) Chr. Chromosome 2 (human) Band 2q36.3 Start 228,850,526 bp End 229,271,287 bp
Gene location (Mouse) Chr. Chromosome 1 (mouse) Band 1|1 C5 Start 84,014,017 bp End 84,341,901 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Descending thoracic aorta ascending aorta gastric mucosa decidua Achilles tendon tibia liver right lobe of liver right adrenal cortex right coronary artery Top expressed in stroma of bone marrow otolith organ utricle piriform cortex molar liver left lobe of liver prostate medial ganglionic eminence calvaria More reference expression data BioGPS n/a
Gene ontology Molecular function protein binding Cellular component cytoplasm Biological process negative regulation of protein phosphorylation cellular response to interleukin-6 cellular response to tumor necrosis factor regulation of reactive oxygen species metabolic process cellular response to leptin stimulus cellular response to cytokine stimulus positive regulation of ATP biosynthetic process regulation of mitochondrial membrane potential negative regulation of insulin receptor signaling pathway negative regulation of glucose import positive regulation of gene expression cellular response to fatty acid positive regulation of reactive oxygen species metabolic process negative regulation of ATP biosynthetic process energy reserve metabolic process mitochondrion morphogenesis fat cell differentiation positive regulation of fat cell proliferation regulation of mitochondrial fusion positive regulation of transcription by RNA polymerase II negative regulation of protein localization to plasma membrane regulation of cell population proliferation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 55022 98496 Ensembl ENSG00000153823 ENSMUSG00000045658 UniProt Q7Z2X4 Q3UBG2 RefSeq (mRNA) NM_001100818 NM_017933 NM_001330156 NM_001330157 NM_001330158 NM_001003948 RefSeq (protein) NP_001094288 NP_001317085 NP_001317086 NP_001317087 NP_060403 NP_001003948 Location (UCSC) Chr 2: 228.85 – 229.27 Mb Chr 1: 84.01 – 84.34 Mb PubMed search
Wikidata
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Further reading

• Wang B, Zhang M, Ni YH, Liu F, Fan HQ, Fei L, Pan XQ, Guo M, Chen RH, Guo XR (September 2006). "Identification and characterization of NYGGF4, a novel gene containing a phosphotyrosine-binding (PTB) domain that stimulates 3T3-L1 preadipocytes proliferation". Gene. 379: 132–40. doi:10.1016/j.gene.2006.05.008. PMID 16815647.
• Caratù G, Allegra D, Bimonte M, Schiattarella GG, D'Ambrosio C, Scaloni A, Napolitano M, Russo T, Zambrano N (February 2007). "Identification of the ligands of protein interaction domains through a functional approach". Mol. Cell. Proteomics. 6 (2): 333–45. doi:10.1074/mcp.M600289-MCP200. PMID 17124247. S2CID 17726406.
• Zhang CM, Chen XH, Wang B, Liu F, Chi X, Tong ML, Ni YH, Chen RH, Guo XR (January 2009). "Over-expression of NYGGF4 inhibits glucose transport in 3T3-L1 adipocytes via attenuated phosphorylation of IRS-1 and Akt". Acta Pharmacol. Sin. 30 (1): 120–4. doi:10.1038/aps.2008.9. PMC 4006536. PMID 19079291.
• Zhang CM, Qiu J, Chen XH, Wang B, Zhang M, Guo XR (October 2009). "[Effects of NYGGF4 gene over-expression on the insulin sensitivity and secretory function of adipocytes]". Zhongguo Dang Dai Er Ke Za Zhi (in Chinese). 11 (10): 846–9. PMID 19849947.
• Hancock DB, Eijgelsheim M, Wilk JB, Gharib SA, Loehr LR, Marciante KD, Franceschini N, van Durme YM, Chen TH, Barr RG, Schabath MB, Couper DJ, Brusselle GG, Psaty BM, van Duijn CM, Rotter JI, Uitterlinden AG, Hofman A, Punjabi NM, Rivadeneira F, Morrison AC, Enright PL, North KE, Heckbert SR, Lumley T, Stricker BH, O'Connor GT, London SJ (January 2010). "Meta-analyses of genome-wide association studies identify multiple loci associated with pulmonary function". Nat. Genet. 42 (1): 45–52. doi:10.1038/ng.500. PMC 2832852. PMID 20010835.
• Zhao Y, Wang J, Cai Y, Chen X, Zhang C, Guo X (February 2010). "[Expression of the NYGGF4 gene during human preadipocyte differentiation and the regulative role of tumor necrosis factor-alpha]". Zhonghua Yi Xue Yi Chuan Xue Za Zhi (in Chinese). 27 (1): 69–72. doi:10.3760/cma.j.issn.1003-9406.2010.01.015 (inactive 1 November 2024). PMID 20140872.{{cite journal}}: CS1 maint: DOI inactive as of November 2024 (link)
• Zhao Y, Zhang C, Chen X, Gao C, Ji C, Chen F, Zhu C, Zhu J, Wang J, Qian L, Guo X (July 2010). "Overexpression of NYGGF4 (PID1) induces mitochondrial impairment in 3T3-L1 adipocytes". Mol. Cell. Biochem. 340 (1–2): 41–8. doi:10.1007/s11010-010-0398-5. PMID 20165904. S2CID 29953818.
• Qiu J, Wang YM, Shi CM, Yue HN, Qin ZY, Zhu GZ, Cao XG, Ji CB, Cui Y, Guo XR (December 2012). "NYGGF4 (PID1) effects on insulin resistance are reversed by metformin in 3T3-L1 adipocytes". J. Bioenerg. Biomembr. 44 (6): 665–71. doi:10.1007/s10863-012-9472-x. PMID 22968630. S2CID 22368210.