PhrS

PhrS is a bacterial small RNA found in Pseudomonas aeruginosa. It was first identified in a RNAomics screen and has since been found to act as a link between oxygen availability and quorum sensing.^[1]

Synthesis of PhrS is dependent on the oxygen-responsive global regulator ANR, which is required for PhrS synthesis. The Hfq protein may also bind to PhrS.^[2] In turn, PhrS regulates the transcriptional regulator PqsR which positively controls those genes involved in quorum sensing regulation in P. aeruginosa.

References

^ Sonnleitner, E.; Sorger-Domenigg, T.; Madej, M. J.; Findeiss, S.; Hackermuller, J.; Huttenhofer, A.; Stadler, P. F.; Blasi, U.; Moll, I. (2008). "Detection of small RNAs in Pseudomonas aeruginosa by RNomics and structure-based bioinformatic tools". Microbiology. 154 (10): 3175–3187. doi:10.1099/mic.0.2008/019703-0. PMID 18832323.
^ Sonnleitner, E.; Gonzalez, N.; Sorger-Domenigg, T.; Heeb, S.; Richter, A. S.; Backofen, R.; Williams, P.; Hüttenhofer, A.; Haas, D.; Bläsi, U. (2011). "The small RNA PhrS stimulates synthesis of the Pseudomonas aeruginosa quinolone signal". Molecular Microbiology. 80 (4): 868–885. doi:10.1111/j.1365-2958.2011.07620.x. PMID 21375594. S2CID 45876403.

[1] Sonnleitner, E.; Sorger-Domenigg, T.; Madej, M. J.; Findeiss, S.; Hackermuller, J.; Huttenhofer, A.; Stadler, P. F.; Blasi, U.; Moll, I. (2008). "Detection of small RNAs in Pseudomonas aeruginosa by RNomics and structure-based bioinformatic tools". Microbiology. 154 (10): 3175–3187. doi:10.1099/mic.0.2008/019703-0. PMID 18832323.

[2] Sonnleitner, E.; Gonzalez, N.; Sorger-Domenigg, T.; Heeb, S.; Richter, A. S.; Backofen, R.; Williams, P.; Hüttenhofer, A.; Haas, D.; Bläsi, U. (2011). "The small RNA PhrS stimulates synthesis of the Pseudomonas aeruginosa quinolone signal". Molecular Microbiology. 80 (4): 868–885. doi:10.1111/j.1365-2958.2011.07620.x. PMID 21375594. S2CID 45876403.

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