Picacho may refer to:
- Mexico
- Villa de Hidalgo, San Luis Potosí
- Picacho del Diablo, Baja California
- Panama
- United States
- Picacho, California
- Little Picacho Wilderness, California
- Picacho, Arizona
- Picacho Peak State Park, Arizona
- Picacho, New Mexico
- Venezuela
- Picacho de El Volcán, Miranda