Pick It Up may refer to:
- "Pick It Up" (Famous Dex song), 2017
- "Pick It Up" (Redman song), 1997
- Pick It Up (Kis-My-Ft2 song), 2017
- "Pick It Up", a song by Fergie from The Dutchess
- "Pick It Up", a song by Lil Mama from VYP (Voice of the Young People)
- "Pick It Up", a song by Luke Bryan from What Makes You Country
- Pick It Up, an album by Planetshakers
- Pick It Up, an album by Relâche