Pike Run may refer to:
- Pike Run (Missouri), a tributary of the Big River in Missouri, United States
- Pike Run (New Jersey), a tributary of Beden Brook in Somerset County, New Jersey, United States
- Pike Run (Ottawa River tributary), a tributary of the Ottawa River in Ohio
- Pike Run (Juniata River tributary), a tributary of the Juniata River in Pennsylvania
This disambiguation page lists articles about distinct geographical locations with the same name.
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