Pixley may refer to:
- Placenames
- Pixley, California, USA
- Pixley, Kansas, USA
- Pixley, Herefordshire, England
- Pixley, Shropshire, England
- Pixley, Wyoming, USA
- Pixley (Green Acres), fictional place in USA
- Surname
- Francis W. Pixley (1852–1933), English accountant and author
- Given Name
- Pixley ka Isaka Seme (1881-1951), a founder and President of the African National Congress